Recently, understanding of the extracellular matrix (ECM) has expanded rapidly due to the
accessibility of cellular and molecular techniques and the growing potential and value for …

Cartilage injury originating from trauma or osteoarthritis is a common joint disease that can
bring about an increasing social and economic burden in modern society. On account of its …

Acute injury of the articular cartilage can lead to chronic disabling conditions because of the
limited self-repair capability of the cartilage. Implantation of stem cells at the injury site is a …

Recently, tissue engineering (TE) is one of the fast growing research fields due the
accessibility of extra-molecular matrix (ECM) at cellular and molecular level with valuable …

Rheumatoid arthritis (RA), a chronic systemic inflammatory disease, is a primary cause of
disability worldwide. The involvement of fibroblast-like synoviocytes (FLSs) in the regulation …

Mesenchymal stem cells (MSCs) hold great promise for the treatment of cartilage related
injuries. However, selectively promoting stem cell differentiation in vivo is still challenging …

Articular cartilage is a highly specialised connective tissue of diarthrodial joints which
provides a smooth, lubricated surface for joint articulation and plays a crucial role in the …

Background Long non-coding RNA heart and neural crest derivatives expressed 2-
antisense RNA 1 (HAND2-AS1) was found to be elevated in rheumatoid arthritis (RA) …

In the field of regenerative medicine, biomaterials play a crucial role since they may serve as
a support (scaffold) to promote cell growth and differentiation in order to promote the healing …

Increasing evidence indicates that decellularized extracellular matrices (dECMs) derived
from cartilage tissues (T-dECMs) or chondrocytes/stem cells (C-dECMs) can support …