Rescuing the last-line polymyxins: achievements and challenges
Antibiotic resistance is a major global health challenge and, worryingly, several key Gram
negative pathogens can become resistant to most currently available antibiotics. Polymyxins …
negative pathogens can become resistant to most currently available antibiotics. Polymyxins …
Epidemiology and treatment of multidrug-resistant and extensively drug-resistant Pseudomonas aeruginosa infections
In recent years, the worldwide spread of the so-called high-risk clones of multidrug-resistant
or extensively drug-resistant (MDR/XDR) Pseudomonas aeruginosa has become a public …
or extensively drug-resistant (MDR/XDR) Pseudomonas aeruginosa has become a public …
Antimicrobial resistance crisis: could artificial intelligence be the solution?
GY Liu, D Yu, MM Fan, X Zhang, ZY Jin, C Tang… - Military Medical …, 2024 - Springer
Antimicrobial resistance is a global public health threat, and the World Health Organization
(WHO) has announced a priority list of the most threatening pathogens against which novel …
(WHO) has announced a priority list of the most threatening pathogens against which novel …
Fitness cost of mcr-1-mediated polymyxin resistance in Klebsiella pneumoniae
Objectives The discovery of mobile colistin resistance mcr-1, a plasmid-borne polymyxin
resistance gene, highlights the potential for widespread resistance to the last-line …
resistance gene, highlights the potential for widespread resistance to the last-line …
Proof-of-principle study in a murine lung infection model of antipseudomonal activity of phage PEV20 in a dry-powder formulation
Bacteriophage therapy is a promising alternative treatment to antibiotics, as it has been
documented to be efficacious against multidrug-resistant bacteria with minimal side effects …
documented to be efficacious against multidrug-resistant bacteria with minimal side effects …
Pharmacokinetics and pharmacodynamics of peptide antibiotics
Antimicrobial resistance is a major global health challenge. As few new efficacious
antibiotics will become available in the near future, peptide antibiotics continue to be major …
antibiotics will become available in the near future, peptide antibiotics continue to be major …
Agents of last resort: an update on polymyxin resistance
The polymyxins, colistin (also known as polymyxin E) and polymyxin B, have a unique and
interesting history. Originally introduced in the 1950s for the treatment of infections owing to …
interesting history. Originally introduced in the 1950s for the treatment of infections owing to …
[HTML][HTML] Outcome of intravenous and inhaled polymyxin B treatment in patients with multidrug-resistant gram-negative bacterial pneumonia
P Ding, H Li, Y Nan, C Liu, G Wang, H Cai… - International Journal of …, 2024 - Elsevier
Purpose The incidence of pneumonia caused by multidrug-resistant gram-negative bacteria
(MDR GNB) is increasing, which imposes significant burden on public health. Inhalation …
(MDR GNB) is increasing, which imposes significant burden on public health. Inhalation …
Spray-freeze-dried inhalable composite microparticles containing nanoparticles of combinational drugs for potential treatment of lung infections caused by …
The multi-drug resistance of Pseudomonas aeruginosa is an overwhelming cause of
terminal and persistent lung infections in cystic fibrosis (CF) patients. Antimicrobial synergy …
terminal and persistent lung infections in cystic fibrosis (CF) patients. Antimicrobial synergy …
Antibiotic pharmacokinetic/pharmacodynamic modelling: MIC, pharmacodynamic indices and beyond
GG Rao, CB Landersdorfer - International Journal of Antimicrobial Agents, 2021 - Elsevier
The dramatic increase in antimicrobial resistance and the limited pharmacological treatment
options highlight the urgent need to optimize therapeutic regimens of new and available anti …
options highlight the urgent need to optimize therapeutic regimens of new and available anti …