Epidemiological, migration, intervention, and genetic studies in humans and animals
provide very strong evidence of a causal link between high salt intake and high blood …

A local renin-angiotensin system (RAS) has been proposed in adipocytes. Adipocytes are a
suggested source of components of the RAS, with regulation of their production related to …

In obese humans and rodents there is increased expression of the key glucocorticoid (GC)
regenerating enzyme, 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), in adipose …

Angiotensin-converting enzyme (ACE) inhibitors are the first-line therapeutic agents for
treating hypertension in patients with the cardiometabolic syndrome and those with …

Chronic diseases, often referred to as noncommunicable diseases (NCDs), usually emerge
in middle age after long exposure to an unhealthy lifestyle involving tobacco use, a lack of …

Hypertension is a common and complex human disease that causes significant morbidity
and mortality worldwide. Unfortunately, despite recent advances in understanding and …

Background—The CYP4A11 arachidonic acid monooxygenase oxidizes endogenous
arachidonic acid (AA) to 20-hydroxyeicosatetraenoic acid (20-HETE), a metabolite with …

In this study of 10 690 individuals, associations with elevated blood pressure, ischemic heart
disease, and ischemic cerebrovascular disease were determined for two noncoding [A …

Abstract Renin–angiotensin (RAS) genes, a group of promising candidate genes involved in
essential hypertension (EH), play a key role in blood pressure regulation. Recently, a series …

Renin-Angiotensin-Aldosterone (RAAS) is a hormone system which acts on multiple
physiologic pathways primarily by regulating blood pressure and fluid balance, but also by …