Tumors are comprised of both cancer cells and surrounding stromal components. As an
essential part of the tumor microenvironment, the tumor stroma is highly dynamic …

Myeloid-derived suppressor cells (MDSCs) are a heterogenic population of immature
myeloid cells with immunosuppressive effects, which undergo massive expansion during …

Immunotherapies have revolutionized the treatment paradigms of various types of cancers.
However, most of these immunomodulatory strategies focus on harnessing adaptive …

Pre-clinical models have shown that targeting pancreatic stellate cells with all-trans-retinoic-
acid (ATRA) reprograms pancreatic stroma to suppress pancreatic ductal adenocarcinoma …

Epidemiological studies are providing strong evidence on beneficial health effects from
dietary measures, leading scientists to actively investigate which foods and which specific …

Peripheral neuropathy is one of the most common side effects of chemotherapy, affecting up
to 60% of all cancer patients receiving chemotherapy. Moreover, paclitaxel induces …

Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …

Targeted drugs have changed cancer treatment but are often ineffective in the long term
against solid tumours, largely because of the activation of heterogeneous oncogenic …

Cancer remains a major killer of mankind. Failure of conventional chemotherapy has
resulted in recurrence and development of virulent multi drug resistant (MDR) phenotypes …

A common key regulator of oncogenic signaling pathways in multiple tumor types is the
unique isomerase Pin1. However, available Pin1 inhibitors lack the required specificity and …