Neurodegenerative diseases are progressive degenerative conditions characterized by the
functional deterioration and ultimate loss of neurons. These incurable and debilitating …

Background: Frontotemporal dementia (FTD) describes a cluster of neurocognitive
syndromes that present with impairment of executive functioning, changes in behavior, and …

Tau (MAPT) drives neuronal dysfunction in Alzheimer disease (AD) and other tauopathies.
To dissect the underlying mechanisms, we combined an engineered ascorbic acid …

We developed stable isotope labeling and mass spectrometry approaches to measure the
kinetics of multiple isoforms and fragments of tau in the human central nervous system …

Frontotemporal dementia (FTD) because of MAPT mutation causes pathological
accumulation of tau and glutamatergic cortical neuronal death by unknown mechanisms. We …

Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by the
progressive accumulation of amyloid-beta and neurofibrillary tangles of tau in the neocortex …

Rapid and efficient protocols to generate oligodendrocytes (OL) from human induced
pluripotent stem cells (iPSC) are currently lacking, but may be a key technology to …

Neurodegenerative diseases resulting from the progressive loss of structure and/or function
of neurons contribute to different paralysis degrees and loss of cognition and sensation. The …

Tau is a microtubule-binding protein expressed in neurons, and the equal ratios between 4-
repeat (4R) and 3-repeat (3R) isoforms are maintained in normal adult brain function …

Alzheimer's disease (AD) transgenic mice have been used as a standard AD model for basic
mechanistic studies and drug discovery. These mouse models showed symbolic AD …