Neurodegeneration leads to the loss of structural and functioning components of neurons
over time. Various studies have related neurodegeneration to a number of degenerative …

In nature's collection of biologically active heterocycles, benzofuran derivatives constitute a
major group. The broad spectrum of pharmacological activity in individual benzofurans …

Background: Alzheimer's disease (AD) is a neurodegenerative disorder with emerging
evidence that it is associated with retinal ganglion cell loss; however, few data exist to …

Highlights•Pathways controlling melatonin secretion are complex.•There are various causes
of melatonin disturbance.•Evaluation of melatonin secretion clinically requires long time …

With increasing feasibility of predicting conversion of mild cognitive impairment to dementia
based on biomarker profiling, the urgent need for efficacious disease‐modifying compounds …

A huge amount of evidence has implicated amyloid beta (Aβ) peptides and other derivatives
of the amyloid precursor protein (βAPP) as central to the pathogenesis of Alzheimer's …

FENE, respectively, and apparent Kd values of 1.86 and 71.2 nM for the low-affinity binding
sites. The traditional radioactive binding assays also produced apparent Kd values in the …

We have utilised laser confocal microscopy to categorise β-amyloid plaque types that are
associated with preclinical and end-stage Alzheimer's disease and to define the …

One of the theories involved in the etiology of Alzheimer's disease (AD) is the oxidative
stress hypothesis. The amyloid β-peptide (Aβ), a hallmark in the pathogenesis of AD and the …

There is increasing evidence to support a role for both the amyloid β-protein precursor
(AβPP) and its proteolytic fragment, amyloid β (Aβ), in metal ion homeostasis. Furthermore …