Abstract N 6-Methyladenosine (m6A) is one of the most abundant modifications of the
epitranscriptome and is found in cellular RNAs across all kingdoms of life. Advances in …

The ability of chemical modifications of single nucleotides to alter the electrostatic charge,
hydrophobic surface and base pairing of RNA molecules is exploited for the clinical use of …

Abstract N 6-methyladenosine (m6A) is the most abundant RNA modification in mammalian
cells and the best-studied epitranscriptomic mark. Despite the development of various tools …

Over the past decade, mRNA modifications have emerged as important regulators of gene
expression control in cells. Fueled in large part by the development of tools for detecting …

Information in mRNA has largely been thought to be confined to its nucleotide sequence.
However, the advent of mapping techniques to detect modified nucleotides has revealed …

RNA modifications have become hot topics recently. By influencing RNA processes,
including generation, transportation, function, and metabolization, they act as critical …

The role of N 6-methyladenosine (m6A) modifications in renal diseases is largely unknown.
Here, we characterized the role of N 6-adenosine-methyltransferase-like 3 (METTL3), whose …

RNA carries a diverse array of chemical modifications that play important roles in the
regulation of gene expression. N 6‐methyladenosine (m6A), installed onto mRNA by the …

The regulation of gene expression is fundamental for life. Whereas the role of transcriptional
regulation of gene expression has been studied for several decades, it has been clear over …

RNA modifications have recently emerged as critical posttranscriptional regulators of gene
expression programmes. Significant advances have been made in understanding the …