Fragment-based drug discovery (FBDD) is a powerful method to develop potent small-
molecule compounds starting from fragments binding weakly to targets. As FBDD exhibits …

Tumor-associated macrophages (TAMs), representing most of the leukocyte population in
solid tumors, demonstrate great phenotypic heterogeneity and diverse functional capabilities …

Background Tenosynovial giant cell tumour (TGCT), a rare, locally aggressive neoplasm,
overexpresses colony-stimulating factor 1 (CSF1). Surgery is standard with no approved …

The colony-stimulating factor 1 receptor (CSF1R) is a key regulator of myeloid lineage cells.
Genetic loss of the CSF1R blocks the normal population of resident microglia in the brain …

Background Expression of the colony-stimulating factor 1 (CSF1) gene is elevated in most
tenosynovial giant-cell tumors. This observation has led to the discovery and clinical …

Diets rich in saturated fat produce inflammation, gliosis, and neuronal stress in the
mediobasal hypothalamus (MBH). Here, we show that microglia mediate this process and its …

Fragment-based drug discovery is a widely used strategy for drug design in both academic
and pharmaceutical industries. Although fragments can be linked to generate candidate …

Tumor-associated macrophages (TAM) plasticity and diversity are both essential hallmarks
of the monocyte-macrophage lineage and the tumor-derived inflammation. TAM exemplify …

Involvement of the immune system in tumour progression is at the forefront of cancer
research. Analysis of the tumour immune microenvironment has yielded a wealth of …

Hematopoietic stem cell transplantation can deliver therapeutic proteins to the central
nervous system (CNS) through transplant-derived microglia-like cells. However, current …