The extracellular matrix (ECM) is a crucial component of the stem cell microenvironment, or
stem-cell niches, and contributes to the regulation of cell behavior and fate. Accumulating …

The cornea is the outermost layer of the eye and plays an essential role in our visual system.
Limbal epithelial stem cells (LESCs), which are localized to a highly regulated limbal niche …

Diabetic keratopathy (DK), the diabetic complication in the cornea, is characterized by the
delayed epithelial regeneration and sensory nerve degeneration. The involvement of limbal …

Organ culture storage techniques for corneoscleral limbal (CSL) tissue have improved the
quality of corneas for transplantation and allow for longer storage times. Cultured limbal …

Purpose: Corneal sensory nerves protect the cornea from injury. They are also thought to
stimulate limbal stem cells (LSCs) to produce transparent epithelial cells constantly …

Purpose: The limbal niche supports the self-renewal of limbal epithelial stem cells (LESCs).
The corneal stromal stem cell (CSSC) is an important component in the niche that regulates …

The cornea is an ideal testing field for cell therapies. Its highly ordered structure, where
specific cell populations are sequestered in different layers, together with its accessibility …

Abstract Corneal Epithelial Stem Cells (CESCs) and their proliferative progeny, the Transit
Amplifying Cells (TACs), are responsible for homeostasis and maintaining corneal …

Chronic epithelial defects of the cornea, which are usually associated with severe dry eye
disease, diabetes mellitus, chemical injuries or neurotrophic keratitis, as well as aging, are …

Human limbal epithelial stem cells (hLESCs) continuously replenish lost or damaged human
corneal epithelial cells. The percentage of stem/progenitor cells in autologous ex vivo …