[HTML][HTML] Innate immunity drives pathogenesis of rheumatoid arthritis

MI Edilova, A Akram, AA Abdul-Sater - Biomedical Journal, 2021 - Elsevier
Rheumatoid arthritis (RA) is an autoimmune disease affecting∼ 1% of the general
population. This disease is characterized by persistent articular inflammation and joint …

Rheumatic manifestations of chikungunya: emerging concepts and interventions

A Suhrbier - Nature Reviews Rheumatology, 2019 - nature.com
The largest epidemic ever recorded for chikungunya, a disease caused by infection with the
chikungunya virus (CHIKV), began in Africa in 2004 and spread to> 100 countries on four …

NK cells in autoimmune diseases: protective or pathogenic?

M Liu, S Liang, C Zhang - Frontiers in Immunology, 2021 - frontiersin.org
Autoimmune diseases generally result from the loss of self-tolerance (ie, failure of the
immune system to distinguish self from non-self), and are characterized by autoantibody …

Cellular metabolic adaptations in rheumatoid arthritis and their therapeutic implications

U Fearon, MM Hanlon, A Floudas… - Nature Reviews …, 2022 - nature.com
Activation of endothelium and immune cells is fundamental to the initiation of autoimmune
diseases such as rheumatoid arthritis (RA), and it results in trans-endothelial cell migration …

Natural killer cells: potential biomarkers and therapeutic target in autoimmune diseases?

E Gianchecchi, DV Delfino, A Fierabracci - Frontiers in immunology, 2021 - frontiersin.org
Autoimmune diseases recognize a multifactorial pathogenesis, although the exact
mechanism responsible for their onset remains to be fully elucidated. Over the past few …

NK cell–derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS

C Louis, F Souza-Fonseca-Guimaraes… - Journal of Experimental …, 2020 - rupress.org
Despite increasing recognition of the importance of GM-CSF in autoimmune disease, it
remains unclear how GM-CSF is regulated at sites of tissue inflammation. Using GM-CSF …

Machine learning to identify immune-related biomarkers of rheumatoid arthritis based on WGCNA network

Y Chen, R Liao, Y Yao, Q Wang, L Fu - Clinical rheumatology, 2022 - Springer
Objectives This study was designed to identify the potential diagnostic biomarkers of
rheumatoid arthritis (RA) and to explore the potential pathological relevance of immune cell …

Natural killer cells in inflammatory autoimmune diseases

Y Yang, J Day… - Clinical & …, 2021 - Wiley Online Library
Natural killer (NK) cells are a specialised population of innate lymphoid cells (ILCs) that help
control local immune responses. Through natural cytotoxicity, production of cytokines and …

N6 -Methyladenosine and Rheumatoid Arthritis: A Comprehensive Review

S Wu, XF Li, YY Wu, SQ Yin, C Huang, J Li - Frontiers in immunology, 2021 - frontiersin.org
Rheumatoid arthritis (RA), one of the most common autoimmune diseases, is characterized
by immune cell infiltration, fibroblast-like synovial cell hyperproliferation, and cartilage and …

Translation of cell therapies to treat autoimmune disorders

JM Mehta, SC Hiremath, C Chilimba, A Ghasemi… - Advanced Drug Delivery …, 2023 - Elsevier
Autoimmune diseases are a diverse and complex set of chronic disorders with a substantial
impact on patient quality of life and a significant global healthcare burden. Current …