Tumor metastasis is a major contributor to the death of cancer patients. It is driven not only
by the intrinsic alterations in tumor cells, but also by the implicated cross-talk between …

Myeloid-derived suppressor cells (MDSC) are one of the major components of the tumor
microenvironment. The main feature of these cells is their potent immune suppressive …

Macrophages represent a heterogeneous cell population and are known to display a
remarkable plasticity. In response to distinct micro-environmental stimuli, eg, tumor stroma …

During tumor progression, circulating monocytes and macrophages are actively recruited
into tumors where they alter the tumor microenvironment to accelerate tumor progression …

CXCR3 is a chemokine receptor with three ligands; CXCL9, CXCL10, and CXCL11.
CXCL11 binds CXCR3 with a higher affinity than the other ligands leading to receptor …

The CCL2 chemokine mediates monocyte egress from bone marrow and recruitment into
inflamed tissues through interaction with the CCR2 chemokine receptor, and its expression …

The role of tumor-associated macrophages (TAMs) in cancer is often correlated with poor
prognosis, even though this statement should be interpreted with care, as the effects of …

Inflammation is now a well-recognized hallmark of cancer progression. Tumor-associated
macrophages (TAMs) are one of the major inflammatory cells that infiltrate murine and …

The response of the body to a cancer is not a unique mechanism but has many parallels
with inflammation and wound healing. This article reviews the links between cancer and …

Mononuclear phagocytes are versatile cells that can express different functional programs in
response to microenvironmental signals. Fully polarized M1 and M2 (or alternatively …