Melioidosis

WJ Wiersinga, HS Virk, AG Torres, BJ Currie… - Nature reviews Disease …, 2018 - nature.com
Burkholderia pseudomallei is a Gram-negative environmental bacterium and the
aetiological agent of melioidosis, a life-threatening infection that is estimated to account …

[HTML][HTML] Innate immune function by Toll-like receptors: distinct responses in newborns and the elderly

TR Kollmann, O Levy, RR Montgomery, S Goriely - Immunity, 2012 - cell.com
Given the" inborn" nature of the innate immune system, it is surprising to find that innate
immune function does in fact change with age. Similar patterns of distinct Toll-like-receptor …

Microbial Peptidyl-Prolyl cis/trans Isomerases (PPIases): Virulence Factors and Potential Alternative Drug Targets

CM Ünal, M Steinert - Microbiology and molecular biology reviews, 2014 - Am Soc Microbiol
Initially discovered in the context of immunomodulation, peptidyl-prolyl cis/trans isomerases
(PPIases) were soon identified as enzymes catalyzing the rate-limiting protein folding step at …

Molecular Insights into Burkholderia pseudomallei and Burkholderia mallei Pathogenesis

EE Galyov, PJ Brett, D DeShazer - Annual review of …, 2010 - annualreviews.org
Burkholderia pseudomallei and Burkholderia mallei are closely related gram-negative
bacteria that can cause serious diseases in humans and animals. This review summarizes …

Human melioidosis

I Gassiep, M Armstrong, R Norton - Clinical microbiology reviews, 2020 - Am Soc Microbiol
The causative agent of melioidosis, Burkholderia pseudomallei, a tier 1 select agent, is
endemic in Southeast Asia and northern Australia, with increased incidence associated with …

The molecular and cellular basis of pathogenesis in melioidosis: how does Burkholderia pseudomallei cause disease?

NR Lazar Adler, B Govan, M Cullinane… - FEMS microbiology …, 2009 - academic.oup.com
Melioidosis, a febrile illness with disease states ranging from acute pneumonia or
septicaemia to chronic abscesses, was first documented by). The causative agent …

Glanders and the risk for its introduction through the international movement of horses

ANB Kettle, U Wernery - Equine Veterinary Journal, 2016 - Wiley Online Library
Glanders is the contagious zoonotic disease caused by infection with Burkholderia mallei. It
affects primarily horses, donkeys and mules. The disease was eradicated from large areas …

Burkholderia vaccines: are we moving forward?

LC Choh, GH Ong, KM Vellasamy… - Frontiers in cellular …, 2013 - frontiersin.org
The genus Burkholderia consists of diverse species which includes both “friends” and “foes.”
Some of the “friendly” Burkholderia spp. are extensively used in the biotechnological and …

Burkholderia pseudomallei aerosol infection results in differential inflammatory responses in BALB/c and C57Bl/6 mice

GYG Tan, Y Liu, SP Sivalingam… - Journal of medical …, 2008 - microbiologyresearch.org
Melioidosis is caused by the Gram-negative bacterium Burkholderia pseudomallei, whose
portals of entry into the body include subcutaneous, ingestion and inhalation routes. Animal …

Characterization of Burkholderia pseudomallei Strains Using a Murine Intraperitoneal Infection Model and In Vitro Macrophage Assays

SL Welkos, CP Klimko, SJ Kern, JJ Bearss, JA Bozue… - PloS one, 2015 - journals.plos.org
Burkholderia pseudomallei, the etiologic agent of melioidosis, is a gram-negative facultative
intracellular bacterium. This bacterium is endemic in Southeast Asia and Northern Australia …