COVID-19 and the chemical senses: supporting players take center stage

KW Cooper, DH Brann, MC Farruggia, S Bhutani… - Neuron, 2020 - cell.com
The main neurological manifestation of COVID-19 is loss of smell or taste. The high
incidence of smell loss without significant rhinorrhea or nasal congestion suggests that …

[HTML][HTML] Wnt/β-catenin signaling, disease, and emerging therapeutic modalities

R Nusse, H Clevers - Cell, 2017 - cell.com
The WNT signal transduction cascade is a main regulator of development throughout the
animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult …

An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control

H Clevers, KM Loh, R Nusse - science, 2014 - science.org
BACKGROUND In adult mammalian organisms, multiple tissues—including the skin, blood,
stomach, and intestines—are entrapped in a state of permanent regeneration; older cells are …

An evolutionary perspective on food and human taste

PAS Breslin - Current Biology, 2013 - cell.com
The sense of taste is stimulated when nutrients or other chemical compounds activate
specialized receptor cells within the oral cavity. Taste helps us decide what to eat and …

Physiology of the tongue with emphasis on taste transduction

ME Doyle, HU Premathilake, Q Yao… - Physiological …, 2023 - journals.physiology.org
The tongue is a complex multifunctional organ that interacts and senses both interoceptively
and exteroceptively. Although it is easily visible to almost all of us, it is relatively …

Single Lgr5-or Lgr6-expressing taste stem/progenitor cells generate taste bud cells ex vivo

W Ren, BC Lewandowski, J Watson… - Proceedings of the …, 2014 - National Acad Sciences
Leucine-rich repeat-containing G protein-coupled receptor 5 (Lgr5) and its homologs (eg,
Lgr6) mark adult stem cells in multiple tissues. Recently, we and others have shown that …

Progress and renewal in gustation: new insights into taste bud development

LA Barlow - Development, 2015 - journals.biologists.com
The sense of taste, or gustation, is mediated by taste buds, which are housed in specialized
taste papillae found in a stereotyped pattern on the surface of the tongue. Each bud …

Possible use of phytochemicals for recovery from COVID-19-induced anosmia and ageusia

S Koyama, K Kondo, R Ueha, H Kashiwadani… - International Journal of …, 2021 - mdpi.com
The year 2020 became the year of the outbreak of coronavirus, SARS-CoV-2, which
escalated into a worldwide pandemic and continued into 2021. One of the unique symptoms …

[HTML][HTML] Wnt/β-catenin signaling in adult mammalian epithelial stem cells

K Kretzschmar, H Clevers - Developmental biology, 2017 - Elsevier
Adult stem cells self-renew and replenish differentiated cells in various organs and tissues
throughout a mammal's life. Over the last 25 years an ever-growing body of knowledge has …

Inflammation arising from obesity reduces taste bud abundance and inhibits renewal

A Kaufman, E Choo, A Koh, R Dando - PLoS biology, 2018 - journals.plos.org
Despite evidence that the ability to taste is weakened by obesity and can be rescued with
weight loss intervention, few studies have investigated the molecular effects of obesity on …