In people living with HIV (PLWH) who are failing or unable to access combination
antiretroviral therapy (cART), monocytes and macrophages are important drivers of …

Although the replicative life cycle of HIV within CD4 T cells is understood in molecular detail,
less is known about how this human retrovirus promotes the loss of CD4 T lymphocytes. It is …

As the role of monocytes and macrophages in a range of diseases is better understood,
strategies to target these cell types are of growing importance both scientifically and …

HIV-1 has evolved mechanisms to evade host cell immune responses and persist for lifelong
infection. Latent cellular reservoirs are responsible for this persistence of HIV-1 despite the …

Human immunodeficiency virus (HIV) and Mycobacterium tuberculosis (Mtb) are pathogens
responsible for millions of new infections each year; together, they cause high morbidity and …

Current antiretroviral therapies have improved the duration and quality of life of people living
with HIV-1. However, viral reservoirs impede complete eradication of the virus. Although …

Review of the role of human M1 and M2 macrophage polarization in HIV-1 infection.
Polarization of MP into classically activated (M1) and alternatively activated (M2a, M2b, and …

HIV infection of macrophages is a critically important component of viral pathogenesis and
progression to AIDS. Although the virus follows the same life cycle in macrophages and T …

OBJECTIVE: To develop a simple and efficient method for producing homogeneous
populations of monocytes and macrophages from human embryonic stem cells (hES) …

Human immunodeficiency virus type 1 (HIV-1) infects both activated CD4+ T cells and
macrophages. We tested if liquid chromatography–tandem mass spectrometry (LC–MS/MS) …