[HTML][HTML] Post-translational modification prediction via prompt-based fine-tuning of a GPT-2 model

P Shrestha, J Kandel, H Tayara, KT Chong - Nature Communications, 2024 - nature.com
Post-translational modifications (PTMs) are pivotal in modulating protein functions and
influencing cellular processes like signaling, localization, and degradation. The complexity …

EMNGly: predicting N-linked glycosylation sites using the language models for feature extraction

X Hou, Y Wang, D Bu, Y Wang, S Sun - Bioinformatics, 2023 - academic.oup.com
Motivation N-linked glycosylation is a frequently occurring post-translational protein
modification that serves critical functions in protein folding, stability, trafficking, and …

[HTML][HTML] Integrating Embeddings from Multiple Protein Language Models to Improve Protein O-GlcNAc Site Prediction

S Pokharel, P Pratyush, HD Ismail, J Ma… - International Journal of …, 2023 - mdpi.com
O-linked β-N-acetylglucosamine (O-GlcNAc) is a distinct monosaccharide modification of
serine (S) or threonine (T) residues of nucleocytoplasmic and mitochondrial proteins. O …

CaLMPhosKAN: Prediction of General Phosphorylation Sites in Proteins via Fusion of Codon Aware Embeddings with Amino Acid Aware Embeddings and Wavelet …

P Pratyush, C Carrier, S Pokharel, HD Ismail… - bioRxiv, 2024 - biorxiv.org
The mapping from codon to amino acid is surjective due to the high degeneracy of the
codon alphabet, suggesting that codon space might harbor higher information content …

[HTML][HTML] Protein feature engineering framework for AMPylation site prediction

H Prabhu, H Bhosale, A Sane, R Dhadwal… - Scientific Reports, 2024 - nature.com
AMPylation is a biologically significant yet understudied post-translational modification
where an adenosine monophosphate (AMP) group is added to Tyrosine and Threonine …

SumoPred-PLM: human SUMOylation and SUMO2/3 sites Prediction using Pre-trained Protein Language Model

AV Palacios, P Acharya, AS Peidl… - NAR Genomics and …, 2024 - academic.oup.com
SUMOylation is an essential post-translational modification system with the ability to
regulate nearly all aspects of cellular physiology. Three major paralogues SUMO1, SUMO2 …

PLM‐T3SE: Accurate Prediction of Type III Secretion Effectors Using Protein Language Model Embeddings

M Gao, C Song, T Liu - Journal of Cellular Biochemistry, 2024 - Wiley Online Library
The Type III secretion effectors (T3SEs) are bacterial proteins synthesized by Gram‐negative
pathogens and delivered into host cells via the Type III secretion system (T3SS). These …

CoNglyPred: Accurate Prediction of N‐Linked Glycosylation Sites Using ESM‐2 and Structural Features With Graph Network and Co‐Attention

H Wang, L Zhao, Z Yu, X Zeng, S Shi - Proteomics, 2024 - Wiley Online Library
ABSTRACT N‐Linked glycosylation is crucial for various biological processes such as
protein folding, immune response, and cellular transport. Traditional experimental methods …

Human O-linked Glycosylation Site Prediction Using Pretrained Protein Language Model

SC Pakhrin, N Chauhan, S Khan, J Upadhyaya… - bioRxiv, 2023 - biorxiv.org
O-linked glycosylation of proteins is an essential post-translational modification process in
Homo sapiens, where the attachment of a sugar moiety occurs at the oxygen atom of serine …

Dynamic Sampling-Based Meta-Learning Using Multilingual Acoustic Data for Under-Resourced Speech Recognition

IT Hsieh, CH Wu, ZH Zhao - IEEE Access, 2024 - ieeexplore.ieee.org
Under-resourced automatic speech recognition (ASR) has become an active field of
research and has experienced significant progress during the past decade. However, the …