Many different globular domains bind to the surfaces of cellular membranes, or to specific
phospholipid components in these membranes, and this binding is often tightly regulated …

Phosphoinositide (PI) lipids are essential components of eukaryotic cell membranes. They
are produced by mono-, bis-and trisphosphorylation of the inositol headgroup of …

ORP5 and ORP8, members of the oxysterol-binding protein (OSBP)-related proteins (ORP)
family, are endoplasmic reticulum membrane proteins implicated in lipid trafficking. ORP5 …

Macropinocytosis can be induced in several cell types by stimulation with growth factors. In
selected cell types, notably macrophages and dendritic cells, macropinocytosis occurs …

Remodeling of extracellular matrix (ECM) is a fundamental cell property that allows cells to
alter their microenvironment and move through tissues. Invadopodia and podosomes are …

Rac and PI3Ks are intracellular signal transducers able to regulate multiple signaling
pathways fundamental for cell behavior. PI3Ks are lipid kinases that produce …

The pleckstrin homology [PH] domain is a structural fold found in more than 250 proteins
making it the 11th most common domain in the human proteome. 25% of family members …

Regulated relocalization of signaling and trafficking proteins is crucial for the control of many
cellular processes and is driven by a series of domains that respond to alterations at …

Protein–metabolite networks are central to biological systems, but are incompletely
understood. Here, we report a screen to catalog protein–lipid interactions in yeast. We used …

Focal adhesion kinase (FAK) is an essential kinase that regulates developmental processes
and functions in the pathology of human disease. An intramolecular autoinhibitory …