Nanoparticle designs for delivery of nucleic acid therapeutics as brain cancer therapies

J Karlsson, KM Luly, SY Tzeng, JJ Green - Advanced drug delivery reviews, 2021 - Elsevier
Glioblastoma (GBM) is an aggressive central nervous system cancer with a dismal
prognosis. The standard of care involves surgical resection followed by radiotherapy and …

Glioblastoma therapy: past, present and future

E Obrador, P Moreno-Murciano… - International journal of …, 2024 - mdpi.com
Glioblastoma (GB) stands out as the most prevalent and lethal form of brain cancer.
Although great efforts have been made by clinicians and researchers, no significant …

Nano-codelivery of temozolomide and siPD-L1 to reprogram the drug-resistant and immunosuppressive microenvironment in orthotopic glioblastoma

D Liu, Y Cheng, S Qiao, M Liu, Q Ji, BL Zhang, Q Mei… - ACS …, 2022 - ACS Publications
Glioblastoma (GBM) is an invasive cancer with high mortality in central nervous system.
Resistance to temozolomide (TMZ) and immunosuppressive microenvironment lead to low …

The role of non-coding RNAs in glioma

A Goenka, DM Tiek, X Song, RP Iglesia, M Lu, B Hu… - Biomedicines, 2022 - mdpi.com
For decades, research in cancer biology has been focused on the protein-coding fraction of
the human genome. However, with the discovery of non-coding RNAs (ncRNAs), it has …

Strategies for improving the safety and RNAi efficacy of noncovalent peptide/siRNA nanocomplexes

J Wang, G Chen, N Liu, X Han, F Zhao, L Zhang… - Advances in Colloid and …, 2022 - Elsevier
In the past decades, the striking development of cationic polypeptides and cell-penetrating
peptides (CPPs) tailored for small interfering RNA (siRNA) delivery has been fuelled by the …

A guide through conventional and modern cancer treatment modalities: A specific focus on glioblastoma cancer therapy

R Naser, H Dilabazian, H Bahr… - Oncology …, 2022 - spandidos-publications.com
Cancer still ranks as one of the top causes of morbidity and mortality despite recent
improvements in standard chemotherapy, radiotherapy, and surgery. This underlines some …

Dendrimer-based delivery of macromolecules for the treatment of brain tumor

H Choudhury, M Pandey, R Mohgan, JSJ Jong… - Biomaterials …, 2022 - Elsevier
Brain tumor represents the most lethal form of cancer with the highest mortality and morbidity
rates irrespective of age and sex. Advancements in macromolecule-based therapy (such as …

Folate targeted hybrid lipo-polymeric nanoplexes containing docetaxel and miRNA-34a for breast cancer treatment

S Sharma, S Pukale, DK Sahel, P Singh, A Mittal… - Materials Science and …, 2021 - Elsevier
In spite of established evidence of the synergistic combination of hydrophobic anticancer
molecule and microRNA for breast cancer treatment, their in vivo delivery has not been …

Multiple therapeutic approaches of glioblastoma multiforme: From terminal to therapy

S Kumari, R Gupta, RK Ambasta, P Kumar - Biochimica et Biophysica Acta …, 2023 - Elsevier
Glioblastoma multiforme (GBM) is an aggressive brain cancer showing poor prognosis.
Currently, treatment methods of GBM are limited with adverse outcomes and low survival …

Construction of surface-modified polydopamine nanoparticles for sequential drug release and combined chemo-photothermal cancer therapy

C Wei, P Wang, Z Huang, D He, W Zhu… - Molecular …, 2021 - ACS Publications
Single chemotherapy often causes severe adverse effects and drug resistance to limit
therapeutic efficacy. As a noninvasive approach, photothermal therapy (PTT) represents an …