Oxidative stress and respiratory diseases in preterm newborns

L Cannavò, S Perrone, V Viola, L Marseglia… - International journal of …, 2021 - mdpi.com
Premature infants are exposed to increased generation of reactive oxygen species, and on
the other hand, they have a deficient antioxidant defense system. Oxidative insult is a salient …

[HTML][HTML] Emerging role of metabolic reprogramming in hyperoxia-associated neonatal diseases

T Sun, H Yu, D Li, H Zhang, J Fu - Redox Biology, 2023 - Elsevier
Oxygen therapy is common during the neonatal period to improve survival, but it can
increase the risk of oxygen toxicity. Hyperoxia can damage multiple organs and systems in …

Human gut microbiome composition and tryptophan metabolites were changed differently by fast food and Mediterranean diet in 4 days: a pilot study

C Zhu, L Sawrey-Kubicek, E Beals, CH Rhodes… - Nutrition Research, 2020 - Elsevier
Diets rich in animal source foods vs plant-based diets have different macronutrient
composition, and they have been shown to have differential effects on the gut microbiome. In …

Whole egg consumption increases plasma choline and betaine without affecting TMAO levels or gut microbiome in overweight postmenopausal women

C Zhu, L Sawrey-Kubicek, AS Bardagjy, H Houts… - Nutrition research, 2020 - Elsevier
As a crucial part of the symbiotic system, the gut microbiome is metabolically connected to
many diseases and conditions, including cardiovascular diseases (CVD). Trimethylamine …

The developing gut–lung axis: postnatal growth restriction, intestinal dysbiosis, and pulmonary hypertension in a rodent model

S Wedgwood, C Warford, SR Agvatisiri, PN Thai… - Pediatric …, 2020 - nature.com
Background Postnatal growth restriction (PNGR) in premature infants increases risk of
pulmonary hypertension (PH). In a rodent model, PNGR causes PH, while combining PNGR …

Oleocanthal-rich extra virgin olive oil demonstrates acute anti-platelet effects in healthy men in a randomized trial

K Agrawal, E Melliou, X Li, TL Pedersen… - Journal of Functional …, 2017 - Elsevier
The phenolic profiles of extra virgin olive oils (EVOOs) may influence their cardiovascular
benefits. In a randomized crossover of acute EVOO intake on platelet function, participants …

[HTML][HTML] Reduced cognitive function, increased blood-brain-barrier transport and inflammatory responses, and altered brain metabolites in LDLr-/-and C57BL/6 mice …

JM Rutkowsky, LL Lee, M Puchowicz, MS Golub… - PLoS …, 2018 - journals.plos.org
Recent work suggests that diet affects brain metabolism thereby impacting cognitive
function. Our objective was to determine if a western diet altered brain metabolism …

Intestinal dysbiosis and the developing lung: the role of toll-like receptor 4 in the gut-lung axis

S Wedgwood, K Gerard, K Halloran… - Frontiers in …, 2020 - frontiersin.org
Background In extremely premature infants, postnatal growth restriction (PNGR) is common
and increases the risk of developing bronchopulmonary dysplasia (BPD) and pulmonary …

Optimal oxygenation and role of free radicals in PPHN

S Wedgwood, RH Steinhorn… - Free Radical Biology and …, 2019 - Elsevier
Effective ventilation of the lungs is essential in mediating pulmonary vasodilation at birth to
allow effective gas exchange and an increase in systemic oxygenation. Unsuccessful …

Umbilical cord blood metabolomics reveal distinct signatures of dyslipidemia prior to bronchopulmonary dysplasia and pulmonary hypertension

MR La Frano, JF Fahrmann, D Grapov… - … of Physiology-Lung …, 2018 - journals.physiology.org
Pulmonary hypertension (PH) is a common consequence of bronchopulmonary dysplasia
(BPD) and remains a primary contributor to increased morbidity and mortality among …