Click chemistry is an immensely powerful technique for the fast and efficient covalent
conjugation of molecular entities. Its broad scope has positively impacted on multiple …

Eukaryotic mRNA with its 5′-cap is of central importance for the cell. Many studies involving
mRNA require reliable preparation and modification of 5′-capped RNAs. Depending on the …

DNA polymerases can process a wide variety of structurally diverse nucleotide substrates,
but the molecular basis by which the analogs are processed is not completely understood …

The global coronavirus pandemic continues to restrict public life worldwide. An effective
means of limiting the pandemic is vaccination. Messenger ribonucleic acid (mRNA) vaccines …

The introduction of chemical modifications into long RNA molecules at specific positions for
visualization, biophysical investigations, diagnostic and therapeutic applications still …

Cellular RNA labeling strategies based on bioorthogonal chemical reactions are much less
developed in comparison to glycan, protein and DNA due to its inherent instability and lack …

Here we describe a protocol for NAD captureSeq that allows for the identification of
nicotinamide-adenine dinucleotide (NAD)-capped RNA sequences in total RNA samples …

Advances in RNA research and RNA nanotechnology depend on the ability to manipulate
and probe RNA with high precision through chemical approaches, both in vitro and in …

Real‐time tracking of RNA expression can provide insight into the mechanisms used to
generate cellular diversity, as well as help determine the underlying causes of disease. Here …

In recent years, several noncanonical RNA caps derived from cofactors and metabolites
have been identified. Purine-containing RNA caps have been extensively studied, with …