Alternative animal models of aging research

S Holtze, E Gorshkova, S Braude… - Frontiers in Molecular …, 2021 - frontiersin.org
Most research on mechanisms of aging is being conducted in a very limited number of
classical model species, ie, laboratory mouse (Mus musculus), rat (Rattus norvegicus …

Sex‐specific aging in animals: perspective and future directions

AM Bronikowski, RP Meisel, PR Biga, JR Walters… - Aging …, 2022 - Wiley Online Library
Sex differences in aging occur in many animal species, and they include sex differences in
lifespan, in the onset and progression of age‐associated decline, and in physiological and …

DNA methylation predicts age and provides insight into exceptional longevity of bats

GS Wilkinson, DM Adams, A Haghani, AT Lu… - Nature …, 2021 - nature.com
Exceptionally long-lived species, including many bats, rarely show overt signs of aging,
making it difficult to determine why species differ in lifespan. Here, we use DNA methylation …

Biological clocks as age estimation markers in animals: a systematic review and meta‐analysis

LS Le Clercq, A Kotzé, JP Grobler… - Biological …, 2023 - Wiley Online Library
Various biological attributes associated with individual fitness in animals change predictably
over the lifespan of an organism. Therefore, the study of animal ecology and the work of …

Hibernation telomere dynamics in a shifting climate: insights from wild greater horseshoe bats

ML Power, RD Ransome, S Riquier… - … of the Royal …, 2023 - royalsocietypublishing.org
Hibernation is linked with various hypotheses to explain the extended lifespan of hibernating
mammals compared with their non-hibernating counterparts. Studies on telomeres, markers …

Heritable variation in telomere length predicts mortality in Soay sheep

H Froy, SL Underwood, J Dorrens… - Proceedings of the …, 2021 - National Acad Sciences
Telomere length (TL) is considered an important biomarker of whole-organism health and
aging. Across humans and other vertebrates, short telomeres are associated with increased …

Telomeres in ecology and evolution: A review and classification of hypotheses

M Tobler, D Gómez‐Blanco, A Hegemann… - Molecular …, 2022 - Wiley Online Library
Research on telomeres in the fields of ecology and evolution has been rapidly expanding
over the last two decades. This has resulted in the formulation of a multitude of, often name …

How does early‐life adversity shape telomere dynamics during adulthood? Problems and paradigms

V Marasco, S Smith, F Angelier - BioEssays, 2022 - Wiley Online Library
Although early‐life adversity has been associated with negative consequences during
adulthood, growing evidence shows that such adversity can also lead to subsequent stress …

High heritability of telomere length and low heritability of telomere shortening in wild birds

C Bauch, JJ Boonekamp, P Korsten, E Mulder… - Molecular …, 2022 - Wiley Online Library
Telomere length and telomere shortening predict survival in many organisms. This raises
the question of the contribution of genetic and environmental effects to variation in these …

Telomere heritability and parental age at conception effects in a wild avian population

AM Sparks, LG Spurgin, M van der Velde… - Molecular …, 2022 - Wiley Online Library
Individual variation in telomere length is predictive of health and mortality risk across a
range of species. However, the relative influence of environmental and genetic variation on …