The application of organs-on-a-chip in dental, oral, and craniofacial research

C Huang, F Sanaei, WPR Verdurmen… - Journal of dental …, 2023 - journals.sagepub.com
The current development of microfluidics-based microphysiological systems (MPSs) will
rapidly lead to a paradigm shift from traditional static 2-dimensional cell cultivation towards …

[HTML][HTML] Biomaterial scaffolds for clinical procedures in endodontic regeneration

H Liu, J Lu, Q Jiang, M Haapasalo, J Qian, FR Tay… - Bioactive Materials, 2022 - Elsevier
Regenerative endodontic procedures have been rapidly evolving over the past two decades
and are employed extensively in clinical endodontics. These procedures have been …

Modeling Crevicular Fluid Flow and Host‐Oral Microbiome Interactions in a Gingival Crevice‐on‐Chip

H Makkar, Y Zhou, KS Tan, CT Lim… - Advanced Healthcare …, 2023 - Wiley Online Library
Gingival crevice and gingival crevicular fluid (GCF) flow play a crucial role at the gingiva‐
oral microbiome interface which contributes toward maintaining the balance between …

Macroporous methacrylated hyaluronic acid hydrogel with different pore sizes for in vitro and in vivo evaluation of vascularization

D Lu, Z Zeng, Z Geng, C Guo, D Pei… - Biomedical …, 2022 - iopscience.iop.org
Vascularization of thick hydrogel scaffolds is still a big challenge, because the submicron-or
nano-sized pores seriously restrict endothelial cells adhesion, proliferation and migration …

High‐Throughput Bioprinting of Geometrically‐Controlled Pre‐Vascularized Injectable Microgels for Accelerated Tissue Regeneration

CM Franca, A Athirasala, R Subbiah… - Advanced …, 2023 - Wiley Online Library
Successful integration of cell‐laden tissue constructs with host vasculature depends on the
presence of functional capillaries to provide oxygen and nutrients to the embedded cells …

A microfluidic organ-on-a-chip: into the next decade of bone tissue engineering applied in dentistry

MH Syahruddin, R Anggraeni, ID Ana - Future Science OA, 2023 - Taylor & Francis
A comprehensive understanding of the complex physiological and pathological processes
associated with alveolar bones, their responses to different therapeutics strategies, and cell …

Injectable Tissue-Specific Hydrogel System for Pulp–Dentin Regeneration

Y Han, J Xu, H Chopra, Z Zhang… - Journal of Dental …, 2024 - journals.sagepub.com
The quest for finding a suitable scaffold system that supports cell survival and function and,
ultimately, the regeneration of the pulp–dentin complex remains challenging. Herein, we …

Prevascularization techniques for dental pulp regeneration: potential cell sources, intercellular communication and construction strategies

Q Ruan, S Tan, L Guo, D Ma, J Wen - Frontiers in Bioengineering and …, 2023 - frontiersin.org
One of the difficulties of pulp regeneration is the rapid vascularization of transplanted
engineered tissue, which is crucial for the initial survival of the graft and subsequent pulp …

Construction of dentin-on-a-chip based on microfluidic technology and tissue engineering

H Zhang, L Li, S Wang, X Sun, C Luo, B Hou - Journal of Dentistry, 2024 - Elsevier
Abstract Aim Three-dimensional (3D) cell culture systems perform better in resembling
tissue or organism structures compared with traditional 2D models. Organs-on-chips (OoCs) …

Development of an electrically responsive hydrogel for programmable in situ immobilization within a microfluidic device

I Plazl - Soft Matter, 2021 - pubs.rsc.org
A novel microfluidic channel device with programmable in situ formation of a hydrogel 3D
network was designed. A biocompatible hybrid material consisting of iron ion-crosslinked …