NAD+ metabolism, stemness, the immune response, and cancer
LE Navas, A Carnero - Signal transduction and targeted therapy, 2021 - nature.com
NAD+ was discovered during yeast fermentation, and since its discovery, its important roles
in redox metabolism, aging, and longevity, the immune system and DNA repair have been …
in redox metabolism, aging, and longevity, the immune system and DNA repair have been …
[HTML][HTML] Mitochondrial Sirtuin 3: New emerging biological function and therapeutic target
J Zhang, H Xiang, J Liu, Y Chen, RR He, B Liu - Theranostics, 2020 - ncbi.nlm.nih.gov
Abstract Sirtuin 3 (SIRT3) is one of the most prominent deacetylases that can regulate
acetylation levels in mitochondria, which are essential for eukaryotic life and inextricably …
acetylation levels in mitochondria, which are essential for eukaryotic life and inextricably …
[HTML][HTML] Mitochondrial sirtuins, metabolism, and aging
Maintaining metabolic homeostasis is essential for cellular and organismal health
throughout life. Multiple signaling pathways that regulate metabolism also play critical roles …
throughout life. Multiple signaling pathways that regulate metabolism also play critical roles …
Epigenetics in NAFLD/NASH: Targets and therapy
Recently non-alcoholic fatty liver disease (NAFLD) has grabbed considerable scientific
attention, owing to its rapid increase in prevalence worldwide and growing burden on end …
attention, owing to its rapid increase in prevalence worldwide and growing burden on end …
[HTML][HTML] The role of ALDH2 in tumorigenesis and tumor progression: Targeting ALDH2 as a potential cancer treatment
H Zhang, L Fu - Acta Pharmaceutica Sinica B, 2021 - Elsevier
A major mitochondrial enzyme for protecting cells from acetaldehyde toxicity is aldehyde
dehydrogenase 2 (ALDH2). The correlation between ALDH2 dysfunction and …
dehydrogenase 2 (ALDH2). The correlation between ALDH2 dysfunction and …
[HTML][HTML] Teaching the basics of reactive oxygen species and their relevance to cancer biology: Mitochondrial reactive oxygen species detection, redox signaling, and …
Reactive oxygen species (ROS) have been implicated in tumorigenesis (tumor initiation,
tumor progression, and metastasis). Of the many cellular sources of ROS generation, the …
tumor progression, and metastasis). Of the many cellular sources of ROS generation, the …
The emerging roles of HDACs and their therapeutic implications in cancer
R Hai, D Yang, F Zheng, W Wang, X Han… - European Journal of …, 2022 - Elsevier
Deregulation of protein post-translational modifications is intensively involved in the etiology
of diseases, including degenerative diseases, inflammatory injuries, and cancers …
of diseases, including degenerative diseases, inflammatory injuries, and cancers …
Dual tumor suppressor and tumor promoter action of sirtuins in determining malignant phenotype
V Carafa, L Altucci, A Nebbioso - Frontiers in pharmacology, 2019 - frontiersin.org
Sirtuins (SIRTs), class III histone deacetylases, are differentially expressed in several human
cancers, where they display both oncogenic and tumor-suppressive properties depending …
cancers, where they display both oncogenic and tumor-suppressive properties depending …
Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway
JH Park, JD Burgess, AH Faroqi, NN DeMeo… - Molecular …, 2020 - Springer
Background Misfolding and aggregation of the presynaptic protein alpha-synuclein (αsyn) is
a hallmark of Parkinson's disease (PD) and related synucleinopathies. Although …
a hallmark of Parkinson's disease (PD) and related synucleinopathies. Although …
Interplay between mitochondrial peroxiredoxins and ROS in cancer development and progression
Mitochondria are multifunctional cellular organelles that are major producers of reactive
oxygen species (ROS) in eukaryotes; to maintain the redox balance, they are supplemented …
oxygen species (ROS) in eukaryotes; to maintain the redox balance, they are supplemented …