The risk of onset of cancer is influenced by poorly controlled chronic inflammatory
processes. Inflammatory diseases related to cancer development include inflammatory …

Abstract The sirtuins (SIRT 1–7) comprise a family of NAD+-dependent protein-modifying
enzymes with activities in lysine deacetylation, adenosinediphospho (ADP)-ribosylation …

Nuclear factor erythroid 2-related factor 2 (Nrf2) is an essential component of cellular
defense against a vast variety of endogenous and exogenous insults, including oxidative …

Endometriosis is an inflammatory condition that is associated with progesterone resistance
and cell proliferation, resulting in pain, infertility and pregnancy loss. We previously …

Sirtuins are a highly conserved family of nicotinamide adenine dinucleotide (NAD+)-
dependent protein lysine modifying enzymes with deacetylase, adenosine …

Simple Summary The prevention and treatment of cancer is an ongoing medical challenge.
In the context of personalized medicine, the well-studied polyphenol resveratrol could …

Cellular senescence happens in 2 steps: cell cycle arrest followed, or sometimes preceded,
by gerogenic conversion (geroconversion). Geroconvesrion is a form of growth, a futile …

Background Carcinogenesis is governed by a series of genetic alterations and epigenetic
changes that lead to aberrant patterns in neoplastic cells. Sirtuin-1 (SIRT1), an NAD+ …

Polyphenols are a class of natural compounds widely distributed in fruits, vegetables, and
plants. They have been reported to possess a wide range of activities in prevention and …

Multiple myeloma (MM) cells induce relevant angiogenic effects within the human bone
marrow milieu (huBMM) by the aberrant expression of angiogenic factors. Hypoxia triggers …