Platelets are anucleate cytoplasmic fragments derived from the fragmentation of medullary
megakaryocytes. Activated platelets adhere to the damaged endothelium by means of …

Since the discovery of lysosomes more than 70 years ago, much has been learned about
the functions of these organelles. Lysosomes were regarded as exclusively degradative …

Platelet granules are unique among secretory vesicles in both their content and their life
cycle. Platelets contain three major granule types—dense granules, α-granules, and …

Lysosome‐related organelles (LROs) comprise a diverse group of cell type‐specific,
membrane‐bound subcellular organelles that derive at least in part from the endolysosomal …

The role of platelets has been extensively studied in the context of coagulation and vascular
integrity. Their hemostatic imbalance can lead to known conditions as atherosclerotic …

Inherited platelet disorders resulting from platelet function defects and a normal platelet
count cause a moderate or severe bleeding diathesis. Since the description of Glanzmann …

Endosomal transport is essential for cellular organization and compartmentalization and cell–
cell communication. Sorting endosomes provide a crossroads for various trafficking …

Over the last 100 years the role of platelets in hemostatic events and their production by
megakaryocytes have gradually been defined. Progressively, thrombocytopenia was …

Platelets respond to vascular injury via surface receptor stimulation and signaling events to
trigger aggregation, procoagulant activation, and granule secretion during hemostasis …

Platelets are cytoplasmic fragments generated by megakaryocytes in the bone marrow and
do not possess a nucleus. They contribute to the “Circulome” consisting of all circulating …