5-Hydroxytryptamine (serotonin) in the gastrointestinal tract

MD Gershon - Current opinion in endocrinology, diabetes and …, 2013 - journals.lww.com
5-Hydroxytryptamine (serotonin) in the gastrointestinal trac... : Current Opinion in
Endocrinology, Diabetes and Obesity 5-Hydroxytryptamine (serotonin) in the …

Neuroplasticity and dysfunction after gastrointestinal inflammation

SM Brierley, DR Linden - Nature reviews Gastroenterology & …, 2014 - nature.com
The gastrointestinal tract is innervated by several distinct populations of neurons, whose cell
bodies either reside within (intrinsic) or outside (extrinsic) the gastrointestinal wall. Normally …

Activation of neuronal P2X7 receptor–pannexin-1 mediates death of enteric neurons during colitis

BD Gulbransen, M Bashashati, SA Hirota, X Gui… - Nature medicine, 2012 - nature.com
Inflammatory bowel diseases (IBDs) are chronic relapsing and remitting conditions
associated with long-term gut dysfunction resulting from alterations to the enteric nervous …

[HTML][HTML] Enteric neuroimmune interactions coordinate intestinal responses in health and disease

H Wang, JPP Foong, NL Harris, JC Bornstein - Mucosal immunology, 2022 - Elsevier
The enteric nervous system (ENS) of the gastrointestinal (GI) tract interacts with the local
immune system bidirectionally. Recent publications have demonstrated that such …

[HTML][HTML] Study of tumor necrosis factor receptor in the inflammatory bowel disease

RF Souza, MAF Caetano, HIR Magalhães… - World Journal of …, 2023 - ncbi.nlm.nih.gov
Ulcerative colitis (UC) and Crohn's disease (CD) are part of Inflammatory Bowel Diseases
(IBD) and have pathophysiological processes such as bowel necrosis and enteric neurons …

Enteric glia promote visceral hypersensitivity during inflammation through intercellular signaling with gut nociceptors

W Morales-Soto, J Gonzales, WF Jackson… - Science …, 2023 - science.org
Inflammation in the intestines causes abdominal pain that is challenging to manage. The
terminals of sensory neurons innervating the gut are surrounded by glia. Here, using a …

Age-dependent shift in macrophage polarisation causes inflammation-mediated degeneration of enteric nervous system

L Becker, L Nguyen, J Gill, S Kulkarni, PJ Pasricha… - Gut, 2018 - gut.bmj.com
Objective The enteric nervous system (ENS) undergoes neuronal loss and degenerative
changes with age. The cause of this neurodegeneration is poorly understood. Muscularis …

Neuroinflammation in inflammatory bowel disease

SE Lakhan, A Kirchgessner - Journal of neuroinflammation, 2010 - Springer
Inflammatory bowel disease is a chronic intestinal inflammatory condition, the pathology of
which is incompletely understood. Gut inflammation causes significant changes in neurally …

[HTML][HTML] Enteric glia mediate neuron death in colitis through purinergic pathways that require connexin-43 and nitric oxide

IAM Brown, JL McClain, RE Watson, BA Patel… - Cellular and molecular …, 2016 - Elsevier
Background & Aims The concept of enteric glia as regulators of intestinal homeostasis is
slowly gaining acceptance as a central concept in neurogastroenterology. Yet how glia …

Enteric neuroplasticity evoked by inflammation

V Vasina, G Barbara, L Talamonti, V Stanghellini… - Autonomic …, 2006 - Elsevier
Neuroplastic changes in the enteric nervous system (ENS) may be observed in
physiological states, such as development and aging, or occur as a consequence of different …