Therapeutic advances of targeting receptor tyrosine kinases in cancer

C Tomuleasa, AB Tigu, R Munteanu… - … and Targeted Therapy, 2024 - nature.com
Receptor tyrosine kinases (RTKs), a category of transmembrane receptors, have gained
significant clinical attention in oncology due to their central role in cancer pathogenesis …

A revised nomenclature for the lemur family of protein kinases

GM Mórotz, NA Bradbury, O Caluseriu… - Communications …, 2024 - nature.com
The lemur family of protein kinases has gained much interest in recent years as they are
involved in a variety of cellular processes including regulation of axonal transport and …

Reduced binding of apoE4 to complement factor H promotes amyloid‐β oligomerization and neuroinflammation

L Chernyaeva, G Ratti, L Teirilä, S Fudo, U Rankka… - EMBO …, 2023 - embopress.org
The APOE4 variant of apolipoprotein E (apoE) is the most prevalent genetic risk allele
associated with late‐onset Alzheimer's disease (AD). ApoE interacts with complement …

Anti-depressive effects of Jiao-Tai-Wan on CORT-induced depression in mice by inhibiting inflammation and microglia activation

G Bai, Y Qiao, PC Lo, L Song, Y Yang, L Duan… - Journal of …, 2022 - Elsevier
Abstract Ethnopharmacological relevance Jiao-Tai-Wan (JTW) is a very famous traditional
Chinese medicine formula for the treatment of psychiatric disorders, especially in anxiety …

Comparison of semi-quantitative scoring and artificial intelligence aided digital image analysis of chromogenic immunohistochemistry

J Bencze, M Szarka, B Kóti, W Seo, TG Hortobágyi… - Biomolecules, 2021 - mdpi.com
Semi-quantitative scoring is a method that is widely used to estimate the quantity of proteins
on chromogen-labelled immunohistochemical (IHC) tissue sections. However, it suffers from …

LMTK2 inhibits Ab25-35-elicited ferroptosis, oxidative stress and apoptotic damage in PC12 cells through activating Nrf2/ARE signalling pathway

L Zhang, F Shu - Folia neuropathologica, 2023 - termedia.pl
Abstract Alzheimer's disease (AD), the most common contributor to dementia, is a growing
global health problem. This study aimed to investigate the role of lemur tyrosine kinase 2 …

The lemur tail kinase family in neuronal function and disfunction in neurodegenerative diseases

A Larose, CCJ Miller, GM Mórotz - Cellular and Molecular Life Sciences, 2024 - Springer
The complex neuronal architecture and the long distance of synapses from the cell body
require precisely orchestrated axonal and dendritic transport processes to support key …

LMTK1, a novel modulator of endosomal trafficking in neurons

S Hisanaga, R Wei, A Huo… - Frontiers in Molecular …, 2020 - frontiersin.org
Neurons extend long processes known as axons and dendrites, through which they
communicate with each other. The neuronal circuits formed by the axons and dendrites are …

Lemur tyrosine kinase 2 (LMTK2) level inversely correlates with phospho-tau in neuropathological stages of Alzheimer's disease

J Bencze, M Szarka, V Bencs, RN Szabó, LV Módis… - Brain Sciences, 2020 - mdpi.com
Alzheimer's disease (AD) is the most common neurodegenerative dementia. Mapping the
pathomechanism and providing novel therapeutic options have paramount significance …

[HTML][HTML] Extracellular matrix changes in corneal opacification vary depending on etiology

LV Módis, G Varkoly, J Bencze, TG Hortobágyi… - Molecular …, 2021 - ncbi.nlm.nih.gov
Purpose The purpose of this study is to examine the expression of tenascin-C and matrilin-2
in three different disorders, which frequently require corneal transplantation. These …