Intrinsically disordered proteins and protein regions (IDRs) are abundant in eukaryotic
proteomes and play a wide variety of essential roles. Instead of folding into a stable …

The sheet‐like lipid bilayer is the fundamental structural component of all cell membranes.
Its building blocks are phospholipids and cholesterol. Their amphiphilic structure …

Intrinsically disordered regions (IDRs) play a pivotal role in organellar remodeling. They
transduce signals across membranes, scaffold signaling complexes, and mediate vesicular …

The MARTINI force field is one of the most used coarse-grained models for biomolecular
simulations. Many limitations of the model including the protein–protein overaggregation …

The plasma membrane (PM) of cells is a dynamic structure whose morphology and
composition is in constant flux. PM morphologic changes are particularly relevant for the …

Proteins and peptides with hydrophobic and amphiphilic segments are responsible for many
biological functions. The sensing and generation of membrane curvature are the functions of …

Protein misfolding diseases (PMDs) in humans are characterized by the deposition of
protein aggregates in tissues, including Alzheimer's disease, Parkinson's disease, type 2 …

Interactions between membrane proteins are essential for cell survival but are often poorly
understood. Even the biologically functional ratio of components within a multi-subunit …

Lipid packing defects are known to serve as quantitative indicators for protein binding to lipid
membranes. This paper presents a protocol for mapping molecular lipid detail onto a …

Abstract α-Synuclein (α-syn) is an abundant presynaptic neuronal protein whose
aggregation is strongly associated with Parkinson's disease. It has been proposed that lipid …