The human papillomavirus replication cycle, and its links to cancer progression: a comprehensive review

SV Graham - Clinical science, 2017 - portlandpress.com
HPVs (human papillomaviruses) infect epithelial cells and their replication cycle is intimately
linked to epithelial differentiation. There are over 200 different HPV genotypes identified to …

Human papillomavirus molecular biology and disease association

J Doorbar, N Egawa, H Griffin… - Reviews in medical …, 2015 - Wiley Online Library
Human papillomaviruses (HPVs) have evolved over millions of years to propagate
themselves in a range of different animal species including humans. Viruses that have co …

High-risk human papillomaviral oncogenes E6 and E7 target key cellular pathways to achieve oncogenesis

NSL Yeo-Teh, Y Ito, S Jha - International journal of molecular sciences, 2018 - mdpi.com
Infection with high-risk human papillomavirus (HPV) has been linked to several human
cancers, the most prominent of which is cervical cancer. The integration of the viral genome …

Functional roles of E6 and E7 oncoproteins in HPV-induced malignancies at diverse anatomical sites

V Tomaić - Cancers, 2016 - mdpi.com
Approximately 200 human papillomaviruses (HPVs) infect human epithelial cells, of which
the alpha and beta types have been the most extensively studied. Alpha HPV types mainly …

[HTML][HTML] Human papillomavirus E6 and E7: What remains?

A Vats, O Trejo-Cerro, M Thomas, L Banks - Tumour virus research, 2021 - Elsevier
Decades of research on the human papillomavirus oncogenes, E6 and E7, have given us
huge amounts of data on their expression, functions and structures. We know much about …

Hallmarks of HPV carcinogenesis: The role of E6, E7 and E5 oncoproteins in cellular malignancy

D Estêvão, NR Costa, RMG da Costa… - Biochimica et Biophysica …, 2019 - Elsevier
Human papillomavirus (HPV) is the most common sexually transmitted infectious agent
worldwide, being also responsible for 5% of all human cancers. The integration and …

RETRACTED ARTICLE: Molecular mechanisms in progression of HPV-associated cervical carcinogenesis

SM Gupta, J Mania-Pramanik - Journal of biomedical science, 2019 - Springer
Cervical cancer is the fourth most frequent cancer in women worldwide and a major cause of
mortality in developing countries. Persistent infection with high-risk human papillomavirus …

E6-mediated activation of JNK drives EGFR signalling to promote proliferation and viral oncoprotein expression in cervical cancer

EL Morgan, JA Scarth, MR Patterson… - Cell Death & …, 2021 - nature.com
Human papillomaviruses (HPV) are a major cause of malignancy worldwide, contributing
to~ 5% of all human cancers including almost all cases of cervical cancer and a growing …

The human papillomavirus E6 PDZ binding motif: from life cycle to malignancy

K Ganti, J Broniarczyk, W Manoubi, P Massimi, S Mittal… - Viruses, 2015 - mdpi.com
Cancer-causing HPV E6 oncoproteins are characterized by the presence of a PDZ binding
motif (PBM) at their extreme carboxy terminus. It was long thought that this region of E6 had …

Mechanisms by which HPV induces a replication competent environment in differentiating keratinocytes

CA Moody - Viruses, 2017 - mdpi.com
Human papillomaviruses (HPV) are the causative agents of cervical cancer and are also
associated with other genital malignancies, as well as an increasing number of head and …