Inflammation is an extensively concerted process that confers protection to the host
encountering immune insult. The major inflammatory mediators include IL-1 family …

Nicorandil, an antianginal and potassium channel opener agent, has different useful impacts
on cardiovascular and respiratory systems. Its effect against silicosis has not been discussed …

Significance: Nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S) are, to
date, the identified members of the gasotransmitter family, which consists of gaseous …

Aims Chronic liver disease (CLD) is a serious medical condition affecting patients globally
and pain management poses a unique challenge. ATP-sensitive potassium channels (K …

Nicorandil (NIC) is a well-known anti-anginal agent, which has been recommended as one
of the second-line treatments for chronic stable angina as justified by the European …

Acute lung injury (ALI) is a devastating critical disease characterized by diffuse inflammation
and endothelial dysfunction. Increasing evidence, including from our laboratory, has …

In the current work, the phytochemical composition of a leaf methanol extract from Albizia
anthelmintica was thoroughly investigated. The antioxidant, anti-inflammatory, analgesic …

Previous report indicated that nicorandil potentiated morphine antinociception and
attenuated hepatic injury in liver fibrotic rats. Herein, the underlying mechanisms of …

The pyrazole compound LQFM-021 exhibits vasorelaxant, antinociceptive and anti-
inflammatory activities. Furthermore, it has low toxicity, indicating that this compound may be …

Signaling pathways are interesting fields of study of pathogenesis and treatment trials. We
elucidated the possible protective effects of nicorandil (15 mg/kg/day) and theophylline (20 …