Pathological angiogenesis: mechanisms and therapeutic strategies

AC Dudley, AW Griffioen - Angiogenesis, 2023 - Springer
In multicellular organisms, angiogenesis, the formation of new blood vessels from pre-
existing ones, is an essential process for growth and development. Different mechanisms …

Lymphatic vessel: origin, heterogeneity, biological functions, and therapeutic targets

Z Hu, X Zhao, Z Wu, B Qu, M Yuan, Y Xing… - … and Targeted Therapy, 2024 - nature.com
Lymphatic vessels, comprising the secondary circulatory system in human body, play a
multifaceted role in maintaining homeostasis among various tissues and organs. They are …

The modes of angiogenesis: An updated perspective

AC Dudley, AW Griffioen - Angiogenesis, 2023 - Springer
Following the process of vasculogenesis during development, angiogenesis generates new
vascular structures through a variety of different mechanisms or modes. These different …

Current status of lymphangiogenesis: molecular mechanism, immune tolerance, and application prospect

H Deng, J Zhang, F Wu, F Wei, W Han, X Xu, Y Zhang - Cancers, 2023 - mdpi.com
Simple Summary Lymphatic vessels are low-pressure, blind-ended tubular structures
essential in maintaining tissue fluid homeostasis, immune cell transport, and lipid transport …

The rising impact of angiogenesis research

AW Griffioen, AC Dudley - Angiogenesis, 2022 - Springer
While inhibiting pathological angiogenesis has been long associated with the field of
oncology, recent advances in angiogenesis research have impacted the progress of disease …

Lymphangiogenesis guidance mechanisms and therapeutic implications in pathological states of the cornea

M Patnam, SR Dommaraju, F Masood, P Herbst… - Cells, 2023 - mdpi.com
Corneal lymphangiogenesis is one component of the neovascularization observed in
several inflammatory pathologies of the cornea including dry eye disease and corneal graft …

Angiopoietin-2-induced lymphatic endothelial cell migration drives lymphangiogenesis via the β1 integrin-RhoA-formin axis

RG Akwii, MS Sajib, FT Zahra, P Tullar… - Angiogenesis, 2022 - Springer
Lymphangiogenesis is an essential physiological process but also a determining factor in
vascular-related pathological conditions. Angiopoietin-2 (Ang2) plays an important role in …

The lymphatic vasculature in lung function and respiratory disease

A Trivedi, HO Reed - Frontiers in Medicine, 2023 - frontiersin.org
The lymphatic vasculature maintains tissue homeostasis via fluid drainage in the form of
lymph and immune surveillance due to migration of leukocytes through the lymphatics to the …

[HTML][HTML] Single-nuclei multiomic analyses identify human cardiac lymphatic endothelial cells associated with coronary arteries in the epicardium

SI Travisano, MRM Harrison, ME Thornton, BH Grubbs… - Cell Reports, 2023 - cell.com
Cardiac lymphatic vessels play important roles in fluid homeostasis, inflammation, disease,
and regeneration of the heart. The developing cardiac lymphatics in human fetal hearts are …

Lymphatics in eye fluid homeostasis: minor contributors or significant actors?

M Subileau, D Vittet - Biology, 2021 - mdpi.com
Simple Summary The eye contains fluid compartments whose tight regulation is essential for
proper eye functioning. Lymphatic vessels are known to be important in several …