The biosynthesis of glycans is a highly conserved biological process and found in all
domains of life. The expression of cell surface glycans is increasingly recognized as a target …

Humans and other animals produce a diverse collection of antibodies, many of which bind to
carbohydrate chains, referred to as glycans. These anti-glycan antibodies are a critical part …

Many bacterial pathogens, including the human exclusive pathogen Salmonella Typhi,
express capsular polysaccharides as a crucial virulence factor. Here, through S. Typhi whole …

Human metabolic incorporation of nonhuman sialic acid (Sia) N-glycolylneuraminic acid into
endogenous glycans generates inflammation via preexisting antibodies, which likely …

The alternative pathway (AP) is the phylogenetically oldest arm of the complement system
and may have evolved to mark pathogens for elimination by phagocytes. Studies using …

Located at the tip of cell surface glycoconjugates, sialic acids are at the forefront of host–
microbe interactions and, being easily liberated by sialidase enzymes, are used as …

Background Mast cell activation is critical for the development of allergic diseases. Ligation
of sialic acid–binding immunoglobin-like lectins (Siglecs), such as Siglec-6,-7, and-8 as well …

Sialic acids (Sias) are acidic monosaccharides and red meat is a notable dietary source of
Sia for humans. Among the Sias, N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D …

Lipooligosaccharides are the most abundant cell surface glycoconjugates on the outer
membrane of Gram-negative bacteria. They play important roles in host–microbe …

Glycosphingolipids (GSLs) play numerous roles in cellular processes, including cell
proliferation, apoptosis, inflammation, and cell signaling. Alteration of the GSLs metabolism …