Synthesis of Caged HMG-CoA Reductase Substrates for the Elucidation of Cellular Pathways
RJ O'Connell, NJ Dolphin, G Ferraudi… - The Journal of …, 2024 - ACS Publications
The synthesis of photocaged substrates of the biologically important enzyme HMG-CoA
reductase is reported. HMG-CoA bearing ap-hydroxyphenacyl (pHP) photocage moiety was …
reductase is reported. HMG-CoA bearing ap-hydroxyphenacyl (pHP) photocage moiety was …
Identification of 3-hydroxy-3-methylglutaryl monoacyl-coenzyme A reductase (HMGR) associated with the synthesis of terpenoids in Santalum album L
M Niu, H Yan, X Zhang, Y Zhang, J Li, Y Xiong, Y Li… - Gene, 2025 - Elsevier
Santalum album is an economically important plant in the craft, spices and medicine
industries. The main chemical constituents found in sandalwood essential oils are …
industries. The main chemical constituents found in sandalwood essential oils are …
Short, Enantioselective Synthesis of Mevalonic Acid
RJ Oconnell, NJ Dolphin, O Wiest, P Helquist - 2024 - chemrxiv.org
A new enantioselective synthesis of mevalonic acid that is short, flexible, scalable to gram
amounts, and uses readily available starting materials is reported. Enantioselective …
amounts, and uses readily available starting materials is reported. Enantioselective …
Watching Pseudomonas mevalonii HMG-CoA Reductase in Action
H Patel, V Purohit, C Steussy, T Schmidt, P Helquist… - 2025 - chemrxiv.org
HMG CoA Reductase catalyzed the interconversion of a thioester, HMG CoA, and mevalonic
acid, a key step in the isoprenoid pathway, through a complex reaction mechanism involving …
acid, a key step in the isoprenoid pathway, through a complex reaction mechanism involving …