Analysis of spike protein variants evolved in a novel in vivo long-term replication model for SARS-CoV-2

D Kim, J Kim, M Kim, H Park, S Park… - Frontiers in Cellular …, 2023 - frontiersin.org
Introduction The spectrum of SARS-CoV-2 mutations have increased over time, resulting in
the emergence of several variants of concern. Persistent infection is assumed to be involved …

In vitro and in vivo suppression of SARS‐CoV‐2 replication by a modified, short, cell‐penetrating peptide targeting the C‐terminal domain of the viral spike protein

D Kim, J Kim, S An, M Kim, K Baek… - Journal of Medical …, 2023 - Wiley Online Library
Peptides are promising therapeutic agents for COVID‐19 because of their specificity, easy
synthesis, and ability to be fine‐tuned. We previously demonstrated that a cell‐permeable …

Integrated analysis of miRNA-mRNA expression of newly emerging swine H3N2 influenza virus cross-species infection with tree shrews

Q Wang, Z Liu, X Zeng, Y Zheng, L Lan, X Wang, Z Lai… - Virology Journal, 2024 - Springer
Background Cross-species transmission of zoonotic IAVs to humans is potentially
widespread and lethal, posing a great threat to human health, and their cross-species …

[HTML][HTML] Human metapneumovirus reinfection in aged mice recapitulates increased disease severity in elderly humans infected with human metapneumovirus

OB Parks, T Eddens, Y Zhang, TD Oury… - …, 2023 - journals.aai.org
Human metapneumovirus (HMPV) is a leading cause of respiratory infection in adults> 65 y.
Nearly all children worldwide are seropositive for HMPV by age 5 y, but reinfections occur …

A mouse xenograft long‐term replication yields a SARS‐CoV‐2 Delta mutant with increased lethality

D Kim, M Kim, J Kim, K Baek, H Park… - Journal of Medical …, 2024 - Wiley Online Library
We recently established a long‐term SARS‐CoV‐2 infection model using lung‐cancer
xenograft mice and identified mutations that arose in the SARS‐CoV‐2 genome during long …

Parental Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) Predominates Over Coinfected SARS‐CoV‐2 Delta, Producing Less Lethal Variants in a …

K Baek, D Kim, BM Kang, J Kim… - Journal of Medical …, 2024 - Wiley Online Library
The evolution of SARS‐CoV‐2, which limits public control and treatment, seems to have
occurred through multiple mechanisms, including recombination of cocirculating strains in …

Analysis of SARS-CoV-2 omicron mutations that emerged during long-term replication in a lung cancer xenograft mouse model

K Baek, D Kim, J Kim, BM Kang, H Park, S Park… - Virus Genes, 2024 - Springer
SARS-CoV-2 Omicron has the largest number of mutations among all the known SARS-CoV-
2 variants. The presence of these mutations might explain why Omicron is more infectious …

Analysis of spike protein variants evolved in a novel mouse model of persistent SARS-CoV-2 infection

D Kim, J Kim, M Kim, H Park, S Maharjan, K Baek… - bioRxiv, 2023 - biorxiv.org
SARS-CoV-2 mutation rates have increased over time, resulting in the emergence of several
variants of concern. Persistent infection is assumed to be involved in the evolution of the …

The role of age and complement in CD8+ T cell function during human metapneumovirus (HMPV) infection

OB Parks - 2024 - search.proquest.com
Human metapneumovirus (HMPV) is a leading cause of severe respiratory disease in young
children< 5yrs old, older adults> 65yrs old, and the immunocompromised. HMPV immunity is …

[PDF][PDF] MODERN METHODS AND TECHNOLOGICAL ADVANCES

DRY UYANIKGİL - researchgate.net
The continuous advancement of science and medicine is pivotal in the quest to protect and
improve human health. This book aims to present the latest perspectives in the fields of …