Redox signaling by reactive electrophiles and oxidants

S Parvez, MJC Long, JR Poganik, Y Aye - Chemical reviews, 2018 - ACS Publications
The concept of cell signaling in the context of nonenzyme-assisted protein modifications by
reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely …

Manipulation and motion of organelles and single molecules in living cells

K Norregaard, R Metzler, CM Ritter… - Chemical …, 2017 - ACS Publications
The biomolecule is among the most important building blocks of biological systems, and a
full understanding of its function forms the scaffold for describing the mechanisms of higher …

Brownian yet non-Gaussian diffusion: from superstatistics to subordination of diffusing diffusivities

AV Chechkin, F Seno, R Metzler, IM Sokolov - Physical Review X, 2017 - APS
A growing number of biological, soft, and active matter systems are observed to exhibit
normal diffusive dynamics with a linear growth of the mean-squared displacement, yet with a …

Protein crowding in lipid bilayers gives rise to non-Gaussian anomalous lateral diffusion of phospholipids and proteins

JH Jeon, M Javanainen, H Martinez-Seara, R Metzler… - Physical Review X, 2016 - APS
Biomembranes are exceptionally crowded with proteins with typical protein-to-lipid ratios
being around 1∶ 50− 1∶ 100. Protein crowding has a decisive role in lateral membrane …

The intracellular trafficking mechanism of Lipofectamine-based transfection reagents and its implication for gene delivery

F Cardarelli, L Digiacomo, C Marchini, A Amici… - Scientific reports, 2016 - nature.com
Lipofectamine reagents are widely accepted as “gold-standard” for the safe delivery of
exogenous DNA or RNA into cells. Despite this, a satisfactory mechanism-based …

Inferring entropy production from short experiments

SK Manikandan, D Gupta, S Krishnamurthy - Physical review letters, 2020 - APS
We provide a strategy for the exact inference of the average as well as the fluctuations of the
entropy production in nonequilibrium systems in the steady state, from the measurements of …

Microorganisms maintain crowding homeostasis

J Van Den Berg, AJ Boersma, B Poolman - Nature Reviews …, 2017 - nature.com
Macromolecular crowding affects the mobility of biomolecules, protein folding and stability,
and the association of macromolecules with each other. Local differences in crowding that …

Identifiability analysis for stochastic differential equation models in systems biology

AP Browning, DJ Warne, K Burrage… - Journal of the …, 2020 - royalsocietypublishing.org
Mathematical models are routinely calibrated to experimental data, with goals ranging from
building predictive models to quantifying parameters that cannot be measured. Whether or …

Non-specific interactions govern cytosolic diffusion of nanosized objects in mammalian cells

F Etoc, E Balloul, C Vicario, D Normanno, D Liße… - Nature materials, 2018 - nature.com
The diffusivity of macromolecules in the cytoplasm of eukaryotic cells varies over orders of
magnitude and dictates the kinetics of cellular processes. However, a general description …

Towards a robust criterion of anomalous diffusion

V Sposini, D Krapf, E Marinari, R Sunyer… - Communications …, 2022 - nature.com
Anomalous-diffusion, the departure of the spreading dynamics of diffusing particles from the
traditional law of Brownian-motion, is a signature feature of a large number of complex soft …