Mitochondria, as the powerhouse organelle of cells, are greatly involved in regulating cell
signaling pathways, including those related to the innate and acquired immune systems …

Environmental pollutants and allergens induce oxidative stress and mitochondrial
dysfunction, leading to key features of allergic asthma. Dysregulations in autophagy …

Background Genetic mitochondrial diseases represent a significant challenge to human
health. These diseases are extraordinarily heterogeneous in clinical presentation and …

The term (bronchial) asthma describes a disorder syndrome that comprises several disease
phenotypes, all characterized by chronic inflammation in the bronchial epithelium, with a …

Background Asthma attacks are common, serious, and costly. Individual factors associated
with attacks, such as poor symptom control, are not robust predictors. Objective We …

Aging is associated with a dysregulation of the immune system, leading to a general pro-
inflammatory state of the organism, a process that has been named inflamm-aging …

Background Metal components of environmental PM2. 5 are associated with the
exacerbation of allergic diseases like asthma. In our recent hospital-based population study …

Autophagy is a major self-degradative process through which cytoplasmic material,
including damaged organelles and proteins, are delivered and degraded in the lysosome …

The world is in the midst of a major obesity epidemic, and in the United States, nearly 40% of
the adult population is obese. 1 Obesity is a major risk factor for asthma and is particularly …

Abstract Purpose of the Review The connections between allergy, asthma and metabolic
syndrome are becoming increasingly clear. Recent research suggests a unifying …