Pharmacokinetic considerations related to therapeutic drug monitoring of tacrolimus in kidney transplant patients
LM Andrews, YI Li, BCM De Winter, YY Shi… - Expert opinion on …, 2017 - Taylor & Francis
ABSTRACT Introduction: Tacrolimus (Tac) is the cornerstone of immunosuppressive therapy
after solid organ transplantation and will probably remain so. Excluding belatacept, no new …
after solid organ transplantation and will probably remain so. Excluding belatacept, no new …
Population pharmacokinetic modelling and Bayesian estimation of tacrolimus exposure: is this clinically useful for dosage prediction yet?
This review summarises the available data on the population pharmacokinetics of tacrolimus
and use of Maximum A Posteriori (MAP) Bayesian estimation to predict tacrolimus exposure …
and use of Maximum A Posteriori (MAP) Bayesian estimation to predict tacrolimus exposure …
Tacrolimus: an updated review on delivering strategies for multifarious diseases
From the current trends, tacrolimus (TAC) has become an important therapeutic option for
the optimal individualization of immunosuppressive therapy especially in case of transplant …
the optimal individualization of immunosuppressive therapy especially in case of transplant …
Predicting drug release and degradation kinetics of long-acting microsphere formulations of tacrolimus for subcutaneous injection
GF Gao, M Ashtikar, R Kojima, T Yoshida… - Journal of controlled …, 2021 - Elsevier
Today, tacrolimus represents a cornerstone of immunosuppressive therapy for liver and
kidney transplants and remains subject of preclinical and clinical investigations, aiming at …
kidney transplants and remains subject of preclinical and clinical investigations, aiming at …
Evaluation of tools for annual capture of adherence to immunosuppressive medications after renal transplantation–a single‐centre open prospective trial
MT Gustavsen, K Midtvedt, K Lønning… - Transplant …, 2019 - Wiley Online Library
Annual assessment of adherence would strengthen long‐term outcome assessments from
registry data. The objective of this study was to evaluate tools suitable for annual routine …
registry data. The objective of this study was to evaluate tools suitable for annual routine …
Population pharmacokinetics and Bayesian estimators for refined dose adjustment of a new tacrolimus formulation in kidney and liver transplant patients
JB Woillard, J Debord, C Monchaud… - Clinical …, 2017 - Springer
Background and Objectives A new once-daily formulation of tacrolimus (Envarsus®) has
recently been developed, with alleged different pharmacokinetics from previous tacrolimus …
recently been developed, with alleged different pharmacokinetics from previous tacrolimus …
A potential route to reduce ischemia/reperfusion injury in organ preservation
M Micó-Carnero, MA Zaouali, C Rojano-Alfonso… - Cells, 2022 - mdpi.com
The pathophysiological process of ischemia and reperfusion injury (IRI), an inevitable step
in organ transplantation, causes important biochemical and structural changes that can …
in organ transplantation, causes important biochemical and structural changes that can …
Pharmacokinetics of prolonged-release once-daily formulations of tacrolimus in de novo kidney transplant recipients: a randomized, parallel-group, open-label …
N Kamar, E Cassuto, G Piotti, M Govoni, G Ciurlia… - Advances in …, 2019 - Springer
Introduction Different prolonged-release formulations of tacrolimus are available. To date,
the pharmacokinetic (PK) profile of LCP-tacrolimus (LCPT; Envarsus®) has not been …
the pharmacokinetic (PK) profile of LCP-tacrolimus (LCPT; Envarsus®) has not been …
Pharmacokinetic therapeutic drug monitoring of Advagraf in more than 500 adult renal transplant patients, using an expert system online
P Marquet, A Bedu, C Monchaud… - Therapeutic Drug …, 2018 - journals.lww.com
Background: Immunosuppressant Bayesian dose adjustment (ISBA) is an online expert
system, routinely used by approximately 140 transplantation centers in the world for the …
system, routinely used by approximately 140 transplantation centers in the world for the …
Body composition is associated with tacrolimus pharmacokinetics in kidney transplant recipients
MI Francke, WJ Visser, D Severs… - European Journal of …, 2022 - Springer
Purpose A population pharmacokinetic (popPK) model may be used to improve tacrolimus
dosing and minimize under-and overexposure in kidney transplant recipients. It is unknown …
dosing and minimize under-and overexposure in kidney transplant recipients. It is unknown …