Neuroblastoma (NB) is one of the most frequently occurring neurogenic extracranial solid
cancers in childhood and infancy. Over the years, many pieces of evidence suggested that …

Background Neuroblastoma (NB) is the most common solid extracranial paediatric tumour.
Genome-wide association studies have driven the discovery of common risk variants, but no …

To efficiently tackle certain tumor types, finding new biomarkers for rapid and complete
phenotyping of cancer cells is highly demanded. This is especially the case for the most …

Background Liquid biopsies do not reflect the complete mutation profile of the tumor but
have the potential to identify actionable mutations when tumor biopsies are not available as …

Background FGFR1 regulates cell–cell adhesion and extracellular matrix architecture and
acts as oncogene in several cancers. Potential cancer driver mutations of FGFR1 occur in …

Noncoding cis-regulatory variants have gained interest as cancer drivers, yet progress in
understanding their significance is hindered by the numerous challenges and limitations of …

Cell-free DNA (cfDNA) from the bloodstream has been studied for cancer biomarker
discovery, and chromatin-derived epigenetic features have come into the spotlight for their …

Background Emerging evidence suggests that non-coding somatic single nucleotide
variants (SNVs) in cis-regulatory elements (CREs) contribute to cancer by disrupting gene …

High-Risk neuroblastoma (NB) survival rate is still< 50%, despite treatments being more and
more aggressive. The biggest hurdle liable to cancer therapy failure is the drug resistance …

Genomic aberrations of neuroblastoma occurring in late childhood and adolescence are still
understudied. Publicly available DNA copy number profiles of 556 tumors (discovery set) …