Reprogramming Müller glia to regenerate retinal neurons

M Lahne, M Nagashima, DR Hyde… - Annual Review of …, 2020 - annualreviews.org
In humans, various genetic defects or age-related diseases, such as diabetic retinopathies,
glaucoma, and macular degeneration, cause the death of retinal neurons and profound …

Müller glia-mediated retinal regeneration

H Gao, X Huang, XI Chen, H Xu - Molecular neurobiology, 2021 - Springer
Müller glia originate from neuroepithelium and are the principal glial cells in the retina.
During retinal development, Müller glia are one of the last cell types to be born. In lower …

[HTML][HTML] STAT signaling modifies Ascl1 chromatin binding and limits neural regeneration from Muller glia in adult mouse retina

NL Jorstad, MS Wilken, L Todd, C Finkbeiner… - Cell reports, 2020 - cell.com
Müller glia (MG) serve as sources for retinal regeneration in non-mammalian vertebrates.
We find that this process can be induced in mouse MG, after injury, by transgenic expression …

The chick eye in vision research: An excellent model for the study of ocular disease

CE Wisely, JA Sayed, H Tamez, C Zelinka… - Progress in retinal and …, 2017 - Elsevier
The domestic chicken, Gallus gallus, serves as an excellent model for the study of a wide
range of ocular diseases and conditions. The purpose of this manuscript is to outline some …

Comparative biology of vertebrate retinal regeneration: restoration of vision through cellular reprogramming

L Todd, TA Reh - Cold Spring Harbor Perspectives in …, 2022 - cshperspectives.cshlp.org
The regenerative capacity of the vertebrate retina varies substantially across species.
Whereas fish and amphibians can regenerate functional retina, mammals do not. In this …

NF-κB signaling regulates the formation of proliferating Müller glia-derived progenitor cells in the avian retina

I Palazzo, K Deistler, TV Hoang, S Blackshaw… - …, 2020 - journals.biologists.com
Retinal regeneration is robust in some cold-blooded vertebrates, but this process is
ineffective in warm-blooded vertebrates. Understanding the mechanisms that suppress the …

Midkine is neuroprotective and influences glial reactivity and the formation of Müller glia‐derived progenitor cells in chick and mouse retinas

WA Campbell, A Fritsch‐Kelleher, I Palazzo, T Hoang… - Glia, 2021 - Wiley Online Library
Recent studies suggest midkine (MDK) is involved in the development and regeneration of
the zebrafish retina. We investigate the expression patterns of MDK and related factors, roles …

Heterogeneity in quiescent Müller glia in the uninjured zebrafish retina drive differential responses following photoreceptor ablation

A Krylov, S Yu, K Veen, A Newton, A Ye… - Frontiers in Molecular …, 2023 - frontiersin.org
Introduction Loss of neurons in the neural retina is a leading cause of vision loss. While
humans do not possess the capacity for retinal regeneration, zebrafish can achieve this …

Patterns of NFkB activation resulting from damage, reactive microglia, cytokines, and growth factors in the mouse retina

I Palazzo, L Kelly, L Koenig, AJ Fischer - Experimental neurology, 2023 - Elsevier
Müller glia are a cellular source for neuronal regeneration in vertebrate retinas. However,
the capacity for retinal regeneration varies widely across species. Understanding the …

Transcriptomic sequencing reveals the potential molecular mechanism by which Tetrabromobisphenol A bis (2-hydroxyethyl ether) exposure exerts developmental …

ES Okeke, X Qian, J Che, G Mao, Y Chen, H Xu… - … and Physiology Part C …, 2022 - Elsevier
Tetrabromobisphenol A bis (2-hydroxyethyl ether)(TBBPA-DHEE) is a derivative of
Tetrabromobisphenol A (TBBPA) used as an intermediate flame retardant in engineering …