Main pathogenic mechanisms and recent advances in COPD peripheral skeletal muscle wasting
Chronic obstructive pulmonary disease (COPD) is a worldwide prevalent respiratory disease
mainly caused by tobacco smoke exposure. COPD is now considered as a systemic disease …
mainly caused by tobacco smoke exposure. COPD is now considered as a systemic disease …
The importance of the diaphragm in neuromotor function in the patient with chronic obstructive pulmonary disease
B Bordoni, A Escher, E Compalati… - … Journal of Chronic …, 2023 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) is a constant and chronic narrowing of the
respiratory airways, with numerous associated symptoms, not always related to the …
respiratory airways, with numerous associated symptoms, not always related to the …
Gene polymorphisms associated with heterogeneity and senescence characteristics of sarcopenia in chronic obstructive pulmonary disease
Background Sarcopenia, or loss of skeletal muscle mass and decreased contractile strength,
contributes to morbidity and mortality in patients with chronic obstructive pulmonary disease …
contributes to morbidity and mortality in patients with chronic obstructive pulmonary disease …
L-Isoleucine reverses hyperammonemia-induced myotube mitochondrial dysfunction and post-mitotic senescence
Perturbations in the metabolism of ammonia, a cytotoxic endogenous metabolite, occur in a
number of chronic diseases, with consequent hyperammonemia. Increased skeletal muscle …
number of chronic diseases, with consequent hyperammonemia. Increased skeletal muscle …
An Engineered Anisotropic Skeletal Muscle Organoid‐on‐a‐Chip for Deciphering Muscle Response under Intermittent Hypoxia
J Li, W Zhang, A Liu, Y Lu, L Yu, X Liu… - Advanced Functional …, 2024 - Wiley Online Library
Generating highly organized skeletal muscle tissues that mimics the cellular alignment,
maturation, and contraction of native skeletal muscle remains a challenge in disease …
maturation, and contraction of native skeletal muscle remains a challenge in disease …
Profiling paracrine interactions between hypoxic and normoxic skeletal muscle tissue in a microphysiological system fabricated from 3D printed components
Disrupted blood flow in conditions such as peripheral artery disease and critical limb
ischemia leads to variations in oxygen supply within skeletal muscle tissue, creating regions …
ischemia leads to variations in oxygen supply within skeletal muscle tissue, creating regions …
Differential impact of sex on regulation of skeletal muscle mitochondrial function and protein homeostasis by hypoxia‐inducible factor‐1α in normoxia
Abstract Hypoxia‐inducible factor (HIF)‐1α is continuously synthesized and degraded in
normoxia. During hypoxia, HIF1α stabilization restricts cellular/mitochondrial oxygen …
normoxia. During hypoxia, HIF1α stabilization restricts cellular/mitochondrial oxygen …
Cognition as mediator of pulmonary function and risk of sarcopenia among older adults
Z Hu, L Tang, Y Zhan - BMC Public Health, 2024 - Springer
Background The relationship between lung function and sarcopenia remains ambiguous.
The primary aim of this study was to investigate the potential association between lung …
The primary aim of this study was to investigate the potential association between lung …
Muscle loss phenotype in COPD is associated with adverse outcomes in the UK Biobank
AH Attaway, R Lopez, N Welch, A Bellar… - BMC Pulmonary …, 2024 - Springer
Background Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory
disorder with systemic consequences that can cause a muscle loss phenotype (MLP), which …
disorder with systemic consequences that can cause a muscle loss phenotype (MLP), which …
Altered hypoxia-induced cellular responses and inflammatory profile in lung fibroblasts from COPD patients compared to control subjects
R Martin, M Nora, L Anna, P Olivia, B Leif… - Respiratory …, 2024 - Springer
Background Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease
characterized by chronic bronchitis, emphysema and vascular remodelling. The disease is …
characterized by chronic bronchitis, emphysema and vascular remodelling. The disease is …