The role of inflammation in the pathogenesis of osteoarthritis

YY Chow, KY Chin - Mediators of inflammation, 2020 - Wiley Online Library
A joint is the point of connection between two bones in our body. Inflammation of the joint
leads to several diseases, including osteoarthritis, which is the concern of this review …

The IL-1 family of cytokines and receptors in rheumatic diseases

CA Dinarello - Nature Reviews Rheumatology, 2019 - nature.com
More than any other cytokine family, the 11 members of the IL-1 family are associated with
innate immune responses, which occur in acute inflammation and chronic inflammatory …

Osteoarthritis: toward a comprehensive understanding of pathological mechanism

DI Chen, J Shen, W Zhao, T Wang, L Han, JL Hamilton… - Bone research, 2017 - nature.com
Osteoarthritis (OA) is the most common degenerative joint disease and a major cause of
pain and disability in adult individuals. The etiology of OA includes joint injury, obesity …

The role of inflammatory and anti‐inflammatory cytokines in the pathogenesis of osteoarthritis

P Wojdasiewicz, ŁA Poniatowski… - Mediators of …, 2014 - Wiley Online Library
Osteoarthritis (OA) is the most common chronic disease of human joints. The basis of
pathologic changes involves all the tissues forming the joint; already, at an early stage, it has …

TGFβ/BMP signaling pathway in cartilage homeostasis

NGM Thielen, PM van der Kraan, APM van Caam - Cells, 2019 - mdpi.com
Cartilage homeostasis is governed by articular chondrocytes via their ability to modulate
extracellular matrix production and degradation. In turn, chondrocyte activity is regulated by …

[HTML][HTML] An update on the pathophysiology of osteoarthritis

A Mobasheri, M Batt - Annals of physical and rehabilitation medicine, 2016 - Elsevier
Introduction Osteoarthritis (OA) is one of the most common forms of arthritis. There is
accumulating evidence to suggest that OA is an inflammatory disease of the entire synovial …

Immune modulation of some autoimmune diseases: the critical role of macrophages and neutrophils in the innate and adaptive immunity

KC Navegantes, R de Souza Gomes… - Journal of translational …, 2017 - Springer
Macrophages and neutrophils are key components involved in the regulation of numerous
chronic inflammatory diseases, infectious disorders, and especially certain autoimmune …

[HTML][HTML] Knee osteoarthritis prevalence, risk factors, pathogenesis and features: Part I

B Heidari - Caspian journal of internal medicine, 2011 - ncbi.nlm.nih.gov
Osteoarthritis (OA) a common disease of aged population and one of the leading causes of
disability. Incidence of knee OA is rising by increasing average age of general population …

[HTML][HTML] Mechanism of action of colchicine in the treatment of gout

N Dalbeth, TJ Lauterio, HR Wolfe - Clinical therapeutics, 2014 - Elsevier
Purpose The aims of this article were to systematically review the literature about the
mechanism of action of colchicine in the multimodal pathology of acute inflammation …

Monocytes, macrophages, and their potential niches in synovial joints–therapeutic targets in post-traumatic osteoarthritis?

P Haubruck, MM Pinto, B Moradi, CB Little… - Frontiers in …, 2021 - frontiersin.org
Synovial joints are complex structures that enable normal locomotion. Following injury, they
undergo a series of changes, including a prevalent inflammatory response. This increases …