As the professional antigen-presenting cells of the immune system, dendritic cells (DCs)
sense the microenvironment and shape the ensuing adaptive immune response. DCs can …

The last decade has been somewhat of a renaissance period for the field of macrophage
biology. This renewed interest, combined with the advent of new technologies and …

Radiotherapy (RT) is a highly effective anticancer treatment that is delivered to more than
half of all patients with cancer. In addition to the well-documented direct cytotoxic effects, RT …

Stroke induces a plastic state in the brain. This period of enhanced plasticity leads to the
sprouting of new axons, the formation of new synapses and the remapping of sensory-motor …

For our immune system to contain or eliminate malignant solid tumours, both myeloid and
lymphoid haematopoietic cells must not only extravasate from the bloodstream into the …

Objective Hepatocellular carcinoma (HCC) is increasingly associated with non-alcoholic
steatohepatitis (NASH). HCC immunotherapy offers great promise; however, recent data …

Leukocyte recruitment from the vasculature into tissues is a crucial component of the
immune system but is also key to inflammatory disease. Chemokines are central to this …

Leukocyte migration into tissues depends on the activity of chemokines that form
concentration gradients to guide leukocytes to a specific site. Interaction of chemokines with …

Atherosclerosis is the leading cause of death worldwide and leukocyte recruitment is a key
element of this phenomenon, thus allowing immune cells to enter the arterial wall. There, in …

Rationale: Despite increasing understanding of the prognostic importance of vascular
stiffening linked to perivascular fibrosis in hypertension, the molecular and cellular …