Although monoclonal in origin, most tumors appear to contain a heterogeneous population
of cancer cells. This observation is traditionally explained by postulating variations in tumor …

Cancer is often viewed as a caricature of normal developmental processes, but the extent to
which its cellular heterogeneity truly recapitulates multilineage differentiation processes of …

Senescence is a cell state occurring in vitro and in vivo after successive replication cycles
and/or upon exposition to various stressors. It is characterized by a strong cell cycle arrest …

Recent observations indicate that, in several types of human cancer, only a phenotypic
subset of cancer cells within each tumor is capable of initiating tumor growth. This functional …

Cancer stem cells (CSCs) presumably contribute to tumor progression and drug resistance,
yet their definitive features have remained elusive. Here, simultaneous measurement of …

Tissue engineering strategies to reconstruct tooth roots are an effective therapy for the
treatment of tooth loss. However, strategies to successfully regenerate tooth roots have not …

Increased Notch1 activity has been observed in intestinal tumours, partially accomplished by
β‐catenin‐mediated up‐regulation of the Notch ligand Jagged‐1. Whether further …

The involvement of telomerase in cellular immortalization and senescence has often been
assessed by means of telomerase expression at the RNA level and quantification of …

We developed a clonal WI-38hTERT/GFP-RAF1-ER immortal cell line to study RAF-induced
senescence of human fibroblasts. Activation of the GFP-RAF1-ER kinase by addition of 4 …

Abstract MUSASHI-1 (MSI-1) is a well-established stem cell marker in both normal and
malignant colon cells and it acts by positively regulating the NOTCH pathway through …