IL-6 is involved both in immune responses and in inflammation, hematopoiesis, bone
metabolism and embryonic development. IL-6 plays roles in chronic inflammation (closely …

Immune system acts as a host defensive mechanism protecting against attacking pathogens
and transformed cells, including cancer cells. Th17 cells are a specific subset of T helper …

The beneficial roles of probiotics in lowering the gastrointestinal inflammation and
preventing colorectal cancer have been frequently demonstrated, but their …

The increasing rate of autoimmune disorders and cancer in recent years has been a
controversial issue in all aspects of prevention, diagnosis, prognosis and treatment. Among …

Immune cells in the tumor microenvironment regulate cancer growth. Thus cancer
progression is dependent on the activation or repression of transcription programs involved …

Sirtuin-1 deacetylates proteins and has emerged as a critical regulator of different cellular
processes, particularly inflammation. Basal SIRT1 activity was previously found to limit Th9 …

Peroxisome proliferator-activated receptors (PPARs) belong to the family of ligand-activated
nuclear receptors. The PPAR family consists of three subtypes encoded by three separate …

Simple Summary One of the causes of failure of anticancer therapies is the reprogramming
of lipid metabolism. Cells of innate and adaptive immunity present in the tumor …

Peroxisome proliferator-activated receptors (PPARs) function as nuclear transcription factors
upon the binding of physiological or pharmacological ligands and heterodimerization with …

The bacterial community that colonizes mucosal surfaces helps shape the development and
function of the immune system. The K/BxN autoimmune arthritis model is dependent on the …