The family members of the mitogen-activated protein (MAP) kinases mediate a wide variety
of cellular behaviors in response to extracellular stimuli. One of the four main sub-groups …

The p38 signalling transduction pathway, a Mitogen-activated protein (MAP) kinase
pathway, plays an essential role in regulating many cellular processes including …

We have identified two cell types, each using almost exclusively one of two different CD95
(APO‐1/Fas) signaling pathways. In type I cells, caspase‐8 was activated within seconds …

The c-Jun amino-terminal kinase (JNK) group of MAP kinases has been identified in
mammals and insects. JNK is activated by exposure of cells to cytokines or environmental …

▪ Abstract Apoptosis of mature T lymphocytes preserves peripheral homeostasis and
tolerance by countering the profound changes in the number and types of T cells stimulated …

The p38 family is a highly evolutionarily conserved group of mitogen-activated protein
kinases (MAPKs) that is involved in and helps co-ordinate cellular responses to nearly all …

It is now generally accepted that protein phosphorylation-dephosphorylation has a role in
the regulation of essentially all cellular functions. Thus, it is of interest that this process is …

Cdc42p is an essential GTPase that belongs to the Rho/Rac subfamily of Ras-like GTPases.
These proteins act as molecular switches by responding to exogenous and/or endogenous …

Part of the cellular response to toxins, physical stresses and inflammatory cytokines occurs
by signalling via the stress-activated protein kinase (SAPK) and p38 reactivating kinase …

This review covers recent advances of CD95 signaling. It focuses on CD95-interacting
molecules, formation of the death inducing signaling complex and the role of caspases …