Genome structural variation in human evolution

EJ Hollox, LW Zuccherato, S Tucci - Trends in Genetics, 2022 - cell.com
Structural variation (SV) is a large difference (typically> 100 bp) in the genomic structure of
two genomes and includes both copy number variation and variation that does not change …

TRAIL in oncology: From recombinant TRAIL to nano-and self-targeted TRAIL-based therapies

H Dianat-Moghadam, M Heidarifard, A Mahari… - Pharmacological …, 2020 - Elsevier
TNF-related apoptosis-inducing ligand (TRAIL) selectively induces the apoptosis pathway in
tumor cells leading to tumor cell death. Because TRAIL induction can kill tumor cells, cancer …

A DNA robotic switch with regulated autonomous display of cytotoxic ligand nanopatterns

Y Wang, I Baars, I Berzina, I Rocamonde-Lago… - Nature …, 2024 - nature.com
The clustering of death receptors (DRs) at the membrane leads to apoptosis. With the goal of
treating tumours, multivalent molecular tools that initiate this mechanism have been …

Immune response during hantavirus diseases: implications for immunotherapies and vaccine design

F Saavedra, FE Díaz, A Retamal‐Díaz, C Covián… - …, 2021 - Wiley Online Library
Orthohantaviruses, previously named hantaviruses, cause two emerging zoonotic diseases:
haemorrhagic fever with renal syndrome (HFRS) in Eurasia and hantavirus cardiopulmonary …

Seoul orthohantavirus evades innate immune activation by reservoir endothelial cells

SD Klimaj, A LaPointe, K Martinez, EH Acosta… - PLoS …, 2024 - journals.plos.org
Pathogenic hantaviruses are maintained world-wide within wild, asymptomatic rodent
reservoir hosts, with increasingly frequent human spillover infections resulting in severe …

Innate lymphoid cells are activated in HFRS, and their function can be modulated by hantavirus-induced type I interferons

M García, A Carrasco García, W Weigel, W Christ… - PLoS …, 2024 - journals.plos.org
Hantaviruses cause the acute zoonotic diseases hemorrhagic fever with renal syndrome
(HFRS) and hantavirus pulmonary syndrome (HPS). Infected patients show strong systemic …

Hantavirus inhibits apoptosis by preventing mitochondrial membrane potential loss through up-regulation of the pro-survival factor BCL-2

C Solà-Riera, M García, HG Ljunggren… - PLoS …, 2020 - journals.plos.org
Hantaviruses, zoonotic RNA viruses belonging to the order Bunyavirales, cause two severe
acute diseases in humans, hemorrhagic fever with renal syndrome (HFRS) and hantavirus …

Viruses run: the evasion mechanisms of the antiviral innate immunity by hantavirus

Y Zhang, R Ma, Y Wang, W Sun, Z Yang… - Frontiers in …, 2021 - frontiersin.org
Hantavirus can cause hemorrhagic fever with renal syndrome (HFRS) in Eurasia and
hantavirus pulmonary syndrome (HPS) in America, with high mortality and unknown …

Regulation of innate immune responses by cell death‐associated caspases during virus infection

Y Fang, K Peng - The FEBS Journal, 2022 - Wiley Online Library
Viruses are obligate intracellular pathogens that rely on cellular machinery for successful
replication and dissemination. The host cells encode a number of different strategies to …

Disparate macrophage responses are linked to infection outcome of Hantan virus in humans or rodents

H Ma, Y Yang, T Nie, R Yan, Y Si, J Wei, M Li… - Nature …, 2024 - nature.com
Hantaan virus (HTNV) is asymptomatically carried by rodents, yet causes lethal hemorrhagic
fever with renal syndrome in humans, the underlying mechanisms of which remain to be …