Expression of MicroRNAs in sepsis-related organ dysfunction: a systematic review

A Maiese, A Scatena, A Costantino, E Chiti… - International Journal of …, 2022 - mdpi.com
Sepsis is a critical condition characterized by increased levels of pro-inflammatory cytokines
and proliferating cells such as neutrophils and macrophages in response to microbial …

Modes of action and diagnostic value of miRNAs in sepsis

N Antonakos, C Gilbert, C Theroude… - Frontiers in …, 2022 - frontiersin.org
Sepsis is a clinical syndrome defined as a dysregulated host response to infection resulting
in life-threatening organ dysfunction. Sepsis is a major public health concern associated …

Regulatory role of non-coding RNAs on immune responses during sepsis

S Ghafouri-Fard, T Khoshbakht, BM Hussen… - Frontiers in …, 2021 - frontiersin.org
Sepsis is resulted from a systemic inflammatory response to bacterial, viral, or fungal agents.
The induced inflammatory response by these microorganisms can lead to multiple organ …

Platelet-monocyte aggregates: molecular mediators of thromboinflammation

CC Rolling, TJ Barrett, JS Berger - Frontiers in Cardiovascular …, 2023 - frontiersin.org
Platelets, key facilitators of primary hemostasis and thrombosis, have emerged as crucial
cellular mediators of innate immunity and inflammation. Exemplified by their ability to alter …

Extracellular vesicle‐bound DNA in urine is indicative of kidney allograft injury

I Sedej, M Štalekar, M Tušek Žnidarič… - Journal of …, 2022 - Wiley Online Library
Extracellular vesicle‐bound DNA (evDNA) is an understudied extracellular vesicle (EV)
cargo, particularly in cancer‐unrelated research. Although evDNA has been detected in …

Platelet microparticles enriched in miR-223 reduce ICAM-1-dependent vascular inflammation in septic conditions

B Szilágyi, Z Fejes, Á Rusznyák, F Fenyvesi… - Frontiers in …, 2021 - frontiersin.org
In the process of sepsis, activated platelets shed microvesicles containing microRNAs
(miRNAs), which can be internalized by distinct recipient cells in circulation, consequently …

Integrated transcriptomic and regulatory network analyses uncovers the role of let-7b-5p, SPIB, and HLA-DPB1 in sepsis

M Mohsin, P Singh, S Khan, AK Verma, R Jha… - Scientific reports, 2022 - nature.com
Sepsis has affected millions of populations of all age groups, locations, and sexes
worldwide. Immune systems, either innate or adaptive are dysregulated due to the infection …

Antiplatelet effect of ginkgo diterpene lactone meglumine injection in acute ischemic stroke: A randomized, double‐blind, placebo‐controlled clinical trial

C Chen, H Lv, L Shan, X Long, C Guo… - Phytotherapy …, 2023 - Wiley Online Library
This study was designed to evaluate antiplatelet effect and therapeutic effect of ginkgo
diterpene lactone meglumine injection (GDLI) in acute ischemic stroke (AIS) patients. In this …

Identification and validation of potential miRNAs, as biomarkers for sepsis and associated lung injury: a network-based approach

S Ahmad, MM Ahmed, PMZ Hasan, A Sharma… - Genes, 2020 - mdpi.com
Sepsis is a dysregulated immune response disease affecting millions worldwide. Delayed
diagnosis, poor prognosis, and disease heterogeneity make its treatment ineffective …

Thromboprophylaxis with argatroban in critically ill patients with sepsis: a review

M Bachler, LM Asmis, J Koscielny, T Lang… - Blood Coagulation & …, 2022 - journals.lww.com
During sepsis, an initial prothrombotic shift takes place, in which coagulatory acute-phase
proteins are increased, while anticoagulatory factors and platelet count decrease. Further …