T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

Chimeric antigen receptor T (CAR-T) cell therapy has significantly improved the life
expectancy for patients with refractory or relapse B cell lymphoma. As for B cell acute …

Allogeneic Vγ9Vδ2 (Vδ2) T cells have emerged as attractive candidates for developing
cancer therapy due to their established safety in allogeneic contexts and inherent tumor …

T cells are critical in destroying cancer cells by recognizing antigens presented by MHC
molecules on cancer cells or antigen-presenting cells. Identifying and targeting cancer …

Cytotoxic T lymphocytes (CTLs) play critical antitumor roles, encompassing diverse subsets
including CD4+, NK, and γδ T cells beyond conventional CD8+ CTLs. However, definitive …

Cancer immunotherapies utilizing genetically engineered T cells have emerged as powerful
personalized therapeutic agents showing dramatic preclinical and clinical results …

Although γδ T cells comprise a small population of T cells, they perform important roles in
protecting against infection and suppressing tumors. With their distinct tissue-localizing …

Simple Summary Boosting effector T cell anti-tumor response remains a challenge, in part
owing to the expression of immune checkpoints and their ligands, such as NKG2A and HLA …

γδ T cells are a kind of innate immune T cell. They have not attracted sufficient attention
because they account for only a small proportion of all immune cells, and many basic factors …

Abstract γδ T cells play an important role in disease control in acute myeloid leukemia (AML)
and have become an emerging area of therapeutic interest. These cells represent a minor …