Heart failure exhibits remarkable pathophysiologic heterogeneity. A large body of evidence
suggests that regardless of the underlying etiology, heart failure is associated with induction …

Inflammation has been recognized as a major pathophysiological contributor to the entire
spectrum of human heart failure (HF), including HF with reduced ejection fraction, HF with …

Background ST‐segment–elevation myocardial infarction is associated with an intense
acute inflammatory response and risk of heart failure. We tested whether interleukin‐1 …

Background Enhanced inflammation may lead to exercise intolerance in heart failure with
preserved ejection fraction. The aim of the current study was to determine whether IL …

The NLRP3 inflammasome has been implicated in the development and progression of
heart failure. The aim of this study was to determine the safety of an oral inhibitor of the …

Aims ST-segment elevation myocardial infarction (STEMI) is associated with an intense
acute inflammatory response and an increased risk of death and heart failure (HF). In this …

Inflammation has emerged as an important contributor to heart failure (HF) development and
progression. Current research data highlight the diversity of immune cells, proteins, and …

Progressive remodeling of the heart, resulting in cardiomyocyte (CM) loss and increased
inflammation, fibrosis, and a progressive decrease in cardiac function, are hallmarks of …

Cardiovascular disease (CVD) is one of the greatest public health concerns and is the
leading cause of morbidity and mortality in the United States and worldwide. CVD is a broad …

Cardiovascular diseases continue to be the most imminent health care problems in the
western world, accounting for numerous deaths per year. Heart failure (HF), namely the …