Transforming growth factor-β1 (TGF-β1) is established to be involved in the pathogenesis of
diabetic nephropathy. The diabetic milieu enhances oxidative stress and induces the …

In recent years, a significant amount of research has examined the controversial role of
activin A in cancer. Activin A, a member of the transforming growth factor β (TGFβ) …

Smooth muscle metaplasia (SMM) and fibrotic tissues are frequently seen in endometriotic
lesions, yet the mechanisms underlying their formation are poorly understood. In this study …

Tumor–stroma interactions significantly influence cancer cell metastasis and disease
progression. These interactions are partly comprised of the cross-talk between tumor and …

Oesophageal squamous cell carcinoma (ESCC) has a relatively unfavourable prognosis
due to metastasis and chemoresistance. Our previous research established a …

Transforming growth factor β (TGF-β) signaling either promotes or inhibits tumor formation
and/or progression of many cancer types including squamous cell carcinoma (SCC) …

Remodelling of the extracellular matrix (ECM) has emerged as a key factor in cancer
progression. Proteoglycans, including versican and other hyalectans, represent major …

Background Distant metastasis is the leading cause of death for esophageal squamous cell
carcinoma (ESCC) with limited treatment options and unsatisfactory effectiveness …

Esophageal carcinoma is the sixth leading cause of cancer death globally and the majority
of global cases are esophageal squamous cell carcinoma (ESCC). Difficulty in diagnosis …

Mast cells have been linked to osteoporosis and bone fractures, and in a previous study we
found that mice lacking a major mast cell protease, chymase, develop increased diaphyseal …