The eponymous member of the interferon regulatory factor (IRF) family, IRF1, was originally
identified as a nuclear factor that binds and activates the promoters of type I interferon …

Transcription factors (TFs) influence cell fate by interpreting the regulatory DNA within a
genome. TFs recognize DNA in a specific manner; the mechanisms underlying this …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encodes several proteins
that inhibit host interferon responses. Among these, ORF6 antagonizes interferon signaling …

Background: Sporadic aortic aneurysm and dissection (AAD), caused by progressive aortic
smooth muscle cell (SMC) loss and extracellular matrix degradation, is a highly lethal …

Specific interactions between proteins and DNA are fundamental to many biological
processes. In this review, we provide a revised view of protein-DNA interactions that …

Abstract Interferon regulatory factor 7 (IRF7) was originally identified in the context of Epstein–
Barr virus (EBV) infection, and has since emerged as the crucial regulator of type I …

Enhancers control the location and timing of gene expression and contain the majority of
variants associated with disease,–. The ZRS is arguably the most well-studied vertebrate …

Transcriptional activation of the interferon-β (IFN-β) gene requires assembly of an
enhanceosome containing ATF-2/c-Jun, IRF-3/IRF-7, and NFκB. These factors bind …

The interferon regulatory factor (IRF) family of transcription factors play a vital role in the
human innate antiviral immune responses with production of interferons (IFNs) as a hallmark …

The interferon-β (IFN-β) enhanceosome is a paradigm for understanding the role of
transcription factor complexes in eukaryotic signal integration. Recent structural studies …